{"id":"W2056547365","doi":"10.1503/jpn.090180","title":"Elevated levels of kynurenic acid in the cerebrospinal fluid of patients with bipolar disorder","year":2010,"lang":"en","type":"article","venue":"Journal of Psychiatry and Neuroscience","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Svenska Läkaresällskapet; Bertil Hållstens Forskningsstiftelse; Länsstyrelsen Östergötland; Vetenskapsrådet; Stockholms Läns Landsting; Karolinska Institutet; Ragnar Söderbergs stiftelse","keywords":"Kynurenic acid; Bipolar disorder; Schizophrenia (object-oriented programming); Cerebrospinal fluid; Internal medicine; Psychology; Kynurenine pathway; Medicine; Endocrinology; Kynurenine; Psychiatry; Glutamate receptor; Chemistry; Tryptophan; Lithium (medication)","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001514632,0.0002879841,0.0003348578,0.0004857824,0.0003965962,0.0004739413,0.00007041914,0.0002757225,0.001499475],"category_scores_gemma":[0.001045146,0.0001680803,0.0001143674,0.000261429,0.0001806069,0.0001520336,0.0001503146,0.0002306782,0.0003025627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002441308,"about_ca_system_score_gemma":0.0002096463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002151515,"about_ca_topic_score_gemma":0.002874186,"domain_scores_codex":[0.9998907,0.00001972792,0.00002036961,0.00001994861,0.00002823706,0.00002094506],"domain_scores_gemma":[0.9996877,0.00005985927,0.0001331121,0.000009927875,0.0000456785,0.00006383123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001367582,0.0001279167,0.9573817,0.0001432394,0.00015433,0.001885397,0.0006502825,0.00006819817,0.02379332,0.00003913081,0.0006413519,0.01374748],"study_design_scores_gemma":[0.00004667996,0.000352884,0.9933335,0.00003509212,0.00006985287,0.003724748,0.0004155984,0.0001017011,0.001394089,0.00007216584,0.0004459817,0.000007724332],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984745,0.00090584,0.00005860364,0.00005264019,0.00001315717,0.000006435624,0.0001305213,0.000007716844,0.0003504853],"genre_scores_gemma":[0.9991672,0.000353553,0.000127191,0.00004988862,0.00001607947,0.000006036417,0.000160251,0.000001753494,0.0001180521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002151515,"threshold_uncertainty_score":0.005016267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01331082263326949,"score_gpt":0.2461649207853611,"score_spread":0.2328540981520917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}