{"id":"W2056574347","doi":"10.1126/science.1217849","title":"Melanesian Blond Hair Is Caused by an Amino Acid Change in TYRP1","year":2012,"lang":"en","type":"article","venue":"Science","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Department of Agriculture","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute","keywords":"Missense mutation; Genetics; Mutation; Arginine; Biology; Cysteine; Zoology; Evolutionary biology; Amino acid; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009047043,0.0006715123,0.0002105971,0.0003709212,0.0003058687,0.0001444311,0.0001455908,0.0004072073,0.001666858],"category_scores_gemma":[0.000351212,0.0001343689,0.0002543724,0.0002771153,0.0005191566,0.00009686772,0.0004362489,0.0003334977,0.0002335673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001549323,"about_ca_system_score_gemma":0.0001250129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001386168,"about_ca_topic_score_gemma":0.002092987,"domain_scores_codex":[0.9999006,0.00001507549,0.000008082784,0.00003464697,0.00002182239,0.00001972066],"domain_scores_gemma":[0.9998067,0.00003891288,0.00009435612,0.00001204893,0.00001141763,0.00003647073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009850641,0.00008169386,0.05089826,0.0002570142,0.0001897093,0.1160828,0.0003969895,0.0003026531,0.8132759,0.0003953619,0.0007756946,0.0163589],"study_design_scores_gemma":[0.000124116,0.000805701,0.5230422,0.00009001257,0.000214289,0.3729738,0.0003161093,0.001288909,0.09406878,0.0004307682,0.006592712,0.00005256439],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976628,0.0004557548,0.0006219006,0.00009686161,0.00003093997,0.00001251406,0.0001332362,0.00005603755,0.0009300484],"genre_scores_gemma":[0.9986361,0.0002386489,0.0004367321,0.00004443027,0.00001704289,0.000003509788,0.00006543083,0.00001197898,0.000546129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001666858,"threshold_uncertainty_score":0.005576134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02321452020282774,"score_gpt":0.3036409079955452,"score_spread":0.2804263877927174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}