{"id":"W2056602930","doi":"10.1161/01.cir.103.15.1984","title":"Serpin Protein CrmA Suppresses Hypoxia-Mediated Apoptosis of Ventricular Myocytes","year":2001,"lang":"en","type":"article","venue":"Circulation","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital","funders":"Canadian Institutes of Health Research","keywords":"Cytochrome c; Apoptosis; Hypoxia (environmental); Cell biology; DNA laddering; Mitochondrial permeability transition pore; Myocyte; Caspase; Caspase 3; Mitochondrion; Mitochondrial apoptosis-induced channel; Internal medicine; Biology; Molecular biology; Endocrinology; Medicine; Programmed cell death; Chemistry; Biochemistry; DNA fragmentation; Oxygen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001731215,0.0002408368,0.0002895065,0.0001197725,0.0000941696,0.0002139208,0.0002170306,0.0002164229,0.0007087106],"category_scores_gemma":[0.0001637948,0.00007184978,0.0001861386,0.00006279068,0.0002140801,0.0001605688,0.0001532022,0.0004339859,0.000196446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001619212,"about_ca_system_score_gemma":0.0001854415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001513212,"about_ca_topic_score_gemma":0.0002406697,"domain_scores_codex":[0.9999021,0.00001787527,0.00001389134,0.00002172825,0.00002086326,0.00002350733],"domain_scores_gemma":[0.9997781,0.00004030317,0.00008782838,0.00002495429,0.0000210956,0.000047719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001365198,0.00002649412,0.0001069299,0.00002481677,0.000004636137,0.00004087276,0.000005766779,0.00002632547,0.9988293,0.0000221917,0.00001640914,0.0007597445],"study_design_scores_gemma":[0.00004089879,0.001102564,0.003927905,0.000007935996,0.00002702312,0.00032058,0.00002518401,0.0007765161,0.9923741,0.00002437308,0.001369931,0.000002906328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955665,0.001614895,0.002104338,0.00008595867,0.00003146855,0.00001971412,0.0001247408,0.00007150882,0.0003808626],"genre_scores_gemma":[0.9958621,0.0009008531,0.002034217,0.00005075405,0.00002902136,0.00003602101,0.0002721142,0.00002052609,0.0007943919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007087106,"threshold_uncertainty_score":0.002370834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01257272826131856,"score_gpt":0.2290814318779132,"score_spread":0.2165087036165946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}