{"id":"W2056626899","doi":"10.1021/mp0500521","title":"Rescue of ΔF508 and Other Misprocessed CFTR Mutants by a Novel Quinazoline Compound","year":2005,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Mutant; Quinazoline; Chemistry; Computational biology; Biology; Combinatorial chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007240201,0.0002327208,0.0002582328,0.00008189425,0.00007425751,0.0001458202,0.0002489079,0.0002134573,0.0006783252],"category_scores_gemma":[0.00007240864,0.00006978786,0.0001631984,0.00006336851,0.0001078047,0.0001159956,0.000107174,0.0002934397,0.0002729906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001411892,"about_ca_system_score_gemma":0.0001500812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006336847,"about_ca_topic_score_gemma":0.0008299818,"domain_scores_codex":[0.9999439,0.000008694701,0.000009240354,0.00001180238,0.0000166191,0.000009765736],"domain_scores_gemma":[0.9999536,0.000007985484,0.0000146718,0.000007713409,0.000007002867,0.000009017226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004595702,0.00001316347,0.00006506469,0.00002356977,0.000002061321,0.00005795534,0.000007359346,0.00004788227,0.9990321,0.00003144745,0.00001308373,0.0006603702],"study_design_scores_gemma":[0.00003202151,0.0006948473,0.002319678,0.000005673069,0.00001122576,0.0005312057,0.00001870629,0.0008180489,0.9936311,0.00001672306,0.00191526,0.000005513881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958846,0.001493152,0.001611121,0.00008442737,0.00002274515,0.00003133815,0.0002670796,0.00006444727,0.0005409619],"genre_scores_gemma":[0.9946297,0.0009095188,0.002543752,0.00003628437,0.000007045023,0.00002147917,0.0004646637,0.00001077413,0.001376674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006783252,"threshold_uncertainty_score":0.002269268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03425986496207498,"score_gpt":0.381705939056924,"score_spread":0.3474460740948491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}