{"id":"W2056626899","doi":"10.1021/mp0500521","title":"Rescue of ΔF508 and Other Misprocessed CFTR Mutants by a Novel Quinazoline Compound","year":2005,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Mutant; Quinazoline; Chemistry; Computational biology; Biology; Combinatorial chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001979916,0.0001794851,0.0003158383,0.00009434167,0.00004117913,0.00001739707,0.0001269481,0.00006759494,0.00009758729],"category_scores_gemma":[0.0001702149,0.0001654419,0.00005382003,0.000240421,0.0002313156,0.00005830136,0.00007648231,0.0002380639,0.00001148098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005312207,"about_ca_system_score_gemma":0.00008745249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002409704,"about_ca_topic_score_gemma":0.000008142078,"domain_scores_codex":[0.9985313,0.0000309083,0.0003084154,0.0002772076,0.0005012134,0.0003509484],"domain_scores_gemma":[0.999196,0.0000656884,0.00007160105,0.0002556416,0.0001472437,0.0002638034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003961635,0.0004227644,0.0007195431,0.000282188,0.00009731874,0.00003735964,0.000113416,0.00007006562,0.9917304,0.00005668978,0.0005879309,0.005486155],"study_design_scores_gemma":[0.003763389,0.0001542377,0.0001900817,0.0001023263,0.00009319391,0.0001182382,0.00003561653,0.01177448,0.7805845,0.00002088922,0.2030225,0.0001406506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803979,0.008956543,0.0071738,0.001711568,0.00003719839,0.0005049511,0.0001658474,0.00004762007,0.001004609],"genre_scores_gemma":[0.9839798,0.0001888725,0.01372422,0.001656392,0.00006310604,0.00001126194,0.00001943696,0.0000466864,0.0003102588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.211146,"threshold_uncertainty_score":0.6746523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03425986496207498,"score_gpt":0.381705939056924,"score_spread":0.3474460740948491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}