{"id":"W2056628210","doi":"10.1016/j.febslet.2008.03.005","title":"MeCP2 preferentially binds to methylated linker DNA in the absence of the terminal tail of histone H3 and independently of histone acetylation","year":2008,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Linker DNA; Nucleosome; Histone; Linker; Histone methylation; Acetylation; Chromatin; Histone H3; DNA; Biology; Histone code; Histone octamer; Chemistry; Molecular biology; Biochemistry; Cell biology; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001156976,0.00009457042,0.0001224357,0.00005173383,0.00003302588,0.000002385409,0.0002174142,0.00006422322,0.000005538886],"category_scores_gemma":[0.00002645412,0.00006850131,0.00004608753,0.0001314227,0.0001432605,0.000002879696,0.0000981213,0.00007019599,4.010615e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008834661,"about_ca_system_score_gemma":0.00003684028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006288005,"about_ca_topic_score_gemma":0.00007816622,"domain_scores_codex":[0.9992189,0.00006678558,0.000248221,0.0001736563,0.0001851892,0.0001072611],"domain_scores_gemma":[0.999576,0.000009385401,0.0001367874,0.0002210746,0.0000366233,0.00002015551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005460234,0.00004666582,0.006685111,0.00001954333,0.00001411204,0.000001142251,0.0007295151,0.000100499,0.9914677,0.000005331362,0.0003642038,0.0005115999],"study_design_scores_gemma":[0.0003553854,0.0001020765,0.4644413,0.00001659516,0.000009072935,0.000007949423,0.00005227085,0.000008191876,0.5345652,0.000008447436,0.0003601449,0.0000733723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986936,0.0001351337,0.0001036067,0.000675814,0.00006259408,0.0001942022,0.000009393579,0.00000120119,0.0001244296],"genre_scores_gemma":[0.9990374,0.00007424819,0.0002322597,0.0005465897,0.000005914123,0.000007023027,0.00001263135,0.00000828717,0.00007558923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4577562,"threshold_uncertainty_score":0.2793402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01334085740786015,"score_gpt":0.2614986184677336,"score_spread":0.2481577610598734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}