{"id":"W2056628838","doi":"10.1371/journal.pntd.0002307","title":"Cathelicidin-like Helminth Defence Molecules (HDMs): Absence of Cytotoxic, Anti-microbial and Anti-protozoan Activities Imply a Specific Adaptation to Immune Modulation","year":2013,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de Santé Publique du Québec; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Technology Sydney","keywords":"Biology; Immune system; Cytotoxic T cell; Cathelicidin; Immunology; Schistosoma mansoni; Helminths; Innate immune system; Schistosomiasis; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000005682274,0.0003225791,0.0005383912,0.000167514,0.0002881956,0.00007933844,0.0002142482,0.000165019,0.0002969718],"category_scores_gemma":[0.00007324415,0.0002959736,0.0001379431,0.0002483949,0.0004485488,0.0003665499,0.0001411154,0.0001973614,0.00009637727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003982629,"about_ca_system_score_gemma":0.00005320512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000372617,"about_ca_topic_score_gemma":0.00001441229,"domain_scores_codex":[0.9983492,0.0001649501,0.0004453021,0.0004874507,0.0000882794,0.0004648445],"domain_scores_gemma":[0.9991661,0.0001416348,0.0001985298,0.0002650486,0.000153589,0.00007505927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001846687,0.0003952656,0.001481944,0.00007871976,0.0001110159,0.000003052889,0.0005160883,0.00006525806,0.9945207,0.000239775,0.0004478432,0.00195573],"study_design_scores_gemma":[0.000559543,0.0002112951,0.5868339,0.0001288293,0.00005003645,0.00001570422,0.0004305409,0.0001405455,0.4111738,0.00009721297,0.00007120005,0.0002873788],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959762,0.0007311305,0.001559501,0.0001950807,0.0001079985,0.001026298,0.0002534761,0.0001199618,0.0000303814],"genre_scores_gemma":[0.9987535,0.0001980807,0.0004755118,0.0001147877,0.00005156854,0.0001114965,0.0001480896,0.00003507088,0.0001118468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5853519,"threshold_uncertainty_score":0.9999492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01201683708458266,"score_gpt":0.2107473588320837,"score_spread":0.1987305217475011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}