{"id":"W2056643428","doi":"10.1124/mol.108.045625","title":"Formaldehyde-Activated Pixantrone Is a Monofunctional DNA Alkylator That Binds Selectively to CpG and CpA Doublets","year":2008,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre for Drug Research and Development","funders":"","keywords":"CpG site; Chemistry; DNA; Formaldehyde; Molecular biology; Biophysics; Biochemistry; Biology; DNA methylation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001016504,0.0002730975,0.0002383066,0.0001154341,0.0001943778,0.00001659285,0.0001665556,0.0002027306,0.0002277814],"category_scores_gemma":[0.000005530399,0.0002854335,0.00009780709,0.0001735543,0.00008990301,0.00000868328,0.0001695109,0.0001526157,0.00002119678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004851143,"about_ca_system_score_gemma":0.0001542152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002444479,"about_ca_topic_score_gemma":0.000004498977,"domain_scores_codex":[0.9985294,0.00006342095,0.0001837499,0.0005680714,0.0001763332,0.0004790064],"domain_scores_gemma":[0.9993588,0.000008573343,0.00007816396,0.0001968748,0.0001126602,0.0002449582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007739645,0.00009495045,0.0001454557,0.000007818799,0.0003089475,0.00004157167,0.00009715759,0.00004207432,0.9909552,0.0001187748,0.00611249,0.00130155],"study_design_scores_gemma":[0.001891964,0.0007365448,0.0005361449,0.000002814066,0.0000571573,0.0002083192,0.00001409618,0.00009986734,0.8594087,0.00007615251,0.1366804,0.0002878001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845673,0.0006726491,0.01237282,0.001015706,0.000418404,0.0004294551,0.00004536573,0.00003026041,0.0004480277],"genre_scores_gemma":[0.9871692,0.0003030822,0.0005345518,0.01086948,0.0001981208,0.0002048056,0.00005517392,0.00005092866,0.0006146347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1315465,"threshold_uncertainty_score":0.9999598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0190781342645797,"score_gpt":0.266928108929604,"score_spread":0.2478499746650243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}