{"id":"W2056679196","doi":"10.1093/jnci/djv101","title":"Germline TP53 Variants and Susceptibility to Osteosarcoma","year":2015,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Children’s Oncology Group","keywords":"Osteosarcoma; Germline; Germline mutation; Medicine; Confidence interval; Odds ratio; Li–Fraumeni syndrome; Internal medicine; Oncology; Proportional hazards model; Logistic regression; Mutation; Genetics; Cancer research; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007170353,0.0001122487,0.0002346571,0.0001327904,0.00006663383,0.00002132913,0.000171395,0.00007197256,0.00003803416],"category_scores_gemma":[0.00103894,0.00007626729,0.0001093804,0.0003168169,0.0000976266,0.0001805015,0.00008824959,0.0003348651,0.000008239199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008214123,"about_ca_system_score_gemma":0.001835258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008143306,"about_ca_topic_score_gemma":0.0002394497,"domain_scores_codex":[0.9982892,0.00004463616,0.0003912929,0.0001424577,0.0009891973,0.0001431988],"domain_scores_gemma":[0.9979813,0.00002564761,0.000234375,0.0001390134,0.001313986,0.0003057069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01371961,0.001824251,0.1123271,0.000494213,0.002736262,0.0007768489,0.005811343,0.0367033,0.3239902,0.01328322,0.4151883,0.07314536],"study_design_scores_gemma":[0.01642719,0.001552679,0.3672897,0.001235472,0.0007024076,0.006236274,0.0001257895,0.0009697532,0.02346794,0.006701722,0.5747062,0.0005848814],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746277,0.00117438,0.0005178025,0.01732923,0.003448281,0.0003360665,0.0000590799,0.00001196797,0.002495482],"genre_scores_gemma":[0.9931483,0.00004958237,0.001971716,0.00303754,0.001345456,0.0000060476,0.000002394299,0.00001317992,0.0004257752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3005222,"threshold_uncertainty_score":0.3255668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0866075012609958,"score_gpt":0.3590744441703144,"score_spread":0.2724669429093186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}