{"id":"W2056708882","doi":"10.1021/op8000756","title":"Development of a Pilot-Plant Process for a Nevirapine Analogue HIV NNRT Inhibitor","year":2008,"lang":"en","type":"article","venue":"Organic Process Research & Development","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Nevirapine; Regioselectivity; Palladium; Pilot plant; Combinatorial chemistry; Chemistry; Catalysis; Human immunodeficiency virus (HIV); Pyridine; Organic chemistry; Medicinal chemistry; Virology; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008205589,0.0002459204,0.0003609592,0.0001722984,0.0004065785,0.00001936057,0.0005225248,0.0001337514,0.00009630253],"category_scores_gemma":[0.0004854533,0.0002097933,0.00007525181,0.0006011932,0.0001616762,0.000009995649,0.0002130644,0.0001634324,0.00002588232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000936811,"about_ca_system_score_gemma":0.002091502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002950815,"about_ca_topic_score_gemma":0.00004323305,"domain_scores_codex":[0.9972746,0.00004353757,0.000631403,0.00063985,0.0007650354,0.0006455115],"domain_scores_gemma":[0.9985465,0.00003894814,0.0001397246,0.0002843652,0.0007676541,0.0002228059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002516163,0.0004791884,0.001502971,0.0003939382,0.0002058988,0.000004371273,0.0008976665,0.000002926149,0.9912103,0.000006338533,0.001162447,0.003882361],"study_design_scores_gemma":[0.0006396326,0.0001327366,0.0008190787,0.00009718155,0.00001101897,0.00001376979,0.0002859388,0.00002846927,0.9711019,0.00003245563,0.02655151,0.0002863098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966901,0.0004295766,0.001889447,0.0001795212,0.00001998282,0.0004722263,0.00002982865,0.00001832635,0.0002709918],"genre_scores_gemma":[0.992963,0.0002073203,0.005246155,0.00004374808,0.0001288736,0.0003680592,0.0004341886,0.00004321411,0.0005654949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02538906,"threshold_uncertainty_score":0.8555121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06104530268777567,"score_gpt":0.3329743696836719,"score_spread":0.2719290669958962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}