{"id":"W2056708882","doi":"10.1021/op8000756","title":"Development of a Pilot-Plant Process for a Nevirapine Analogue HIV NNRT Inhibitor","year":2008,"lang":"en","type":"article","venue":"Organic Process Research & Development","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Nevirapine; Regioselectivity; Palladium; Pilot plant; Combinatorial chemistry; Chemistry; Catalysis; Human immunodeficiency virus (HIV); Pyridine; Organic chemistry; Medicinal chemistry; Virology; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003146464,0.0005428691,0.0008141789,0.0002481229,0.0003742975,0.0004602754,0.0006070449,0.0005067977,0.002863166],"category_scores_gemma":[0.0004479758,0.0002682779,0.0004044624,0.0002142995,0.0001904658,0.0003013173,0.0003620815,0.001179307,0.002128818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00026739,"about_ca_system_score_gemma":0.0007304644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001205268,"about_ca_topic_score_gemma":0.001728307,"domain_scores_codex":[0.9997173,0.00003400692,0.00001320831,0.00004960109,0.000147612,0.00003817627],"domain_scores_gemma":[0.9998745,0.00003127481,0.00001807091,0.00001644387,0.00002141357,0.00003817106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001070251,0.0001468181,0.0001050695,0.0001080289,0.000009371835,0.0001334779,0.00002081995,0.0003380434,0.9927396,0.00009333291,0.000109602,0.006088805],"study_design_scores_gemma":[0.00008157239,0.0009722665,0.001047028,0.00001036428,0.00003719734,0.0003706807,0.00002802266,0.002018768,0.9901148,0.00006953801,0.005232484,0.00001727823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7651134,0.001369083,0.2172492,0.0004244486,0.0002255453,0.002711875,0.002039818,0.003395982,0.007470649],"genre_scores_gemma":[0.8320682,0.00141725,0.1552021,0.0001477997,0.00007419215,0.0009281107,0.001845073,0.0002974917,0.008019847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002863166,"threshold_uncertainty_score":0.009578228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06104530268777567,"score_gpt":0.3329743696836719,"score_spread":0.2719290669958962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}