{"id":"W2056712149","doi":"10.1371/journal.pone.0050354","title":"Genetic Variants in the Fat and Obesity Associated (FTO) Gene and Risk of Alzheimer's Disease","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; University of California, Los Angeles; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; BioClinica; Bayer HealthCare; Alzheimer's Disease Neuroimaging Initiative; Biogen; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Amorfix Life Sciences; Dana Foundation; Synarc; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Single-nucleotide polymorphism; FTO gene; Genome-wide association study; SNP; Endophenotype; Obesity; Multiple comparisons problem; Haplotype; Genetic association; Biology; Medicine; Internal medicine; Genetics; Gene; Oncology; Genotype; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005384953,0.0003629575,0.0002872589,0.0006422339,0.0004161455,0.0005627407,0.0002933463,0.0003424881,0.001772737],"category_scores_gemma":[0.00174606,0.0001142452,0.0003015941,0.001283625,0.0002612426,0.00009029623,0.0003032956,0.0003346868,0.0001603457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002442137,"about_ca_system_score_gemma":0.0002654795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01201629,"about_ca_topic_score_gemma":0.01213353,"domain_scores_codex":[0.9996635,0.00007212751,0.0000320685,0.0001430488,0.0000485124,0.00004078244],"domain_scores_gemma":[0.9992552,0.0003102107,0.0002436983,0.00005562424,0.00005260464,0.00008254227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001595039,0.00005398915,0.9843664,0.00006749359,0.0006524815,0.0004252703,0.0001742937,0.0002477303,0.00692085,0.00009350452,0.0002616748,0.005141374],"study_design_scores_gemma":[0.00005892656,0.00005439909,0.9974267,0.00002035671,0.0003107844,0.0004019525,0.00007629206,0.0003640812,0.0005993209,0.0001493265,0.0005315624,0.000006211051],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976532,0.0005562474,0.0002802195,0.00006444508,0.000007309556,0.000008729091,0.0009975565,0.000009689334,0.0004226281],"genre_scores_gemma":[0.9979345,0.0002418067,0.0005081721,0.00003559208,0.00001592387,0.00002274325,0.0009989989,0.000008399294,0.0002339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01201629,"threshold_uncertainty_score":0.0238927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02780799098985166,"score_gpt":0.2370846780116934,"score_spread":0.2092766870218418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}