{"id":"W2056712149","doi":"10.1371/journal.pone.0050354","title":"Genetic Variants in the Fat and Obesity Associated (FTO) Gene and Risk of Alzheimer's Disease","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; University of California, Los Angeles; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; BioClinica; Bayer HealthCare; Alzheimer's Disease Neuroimaging Initiative; Biogen; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Amorfix Life Sciences; Dana Foundation; Synarc; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Single-nucleotide polymorphism; FTO gene; Genome-wide association study; SNP; Endophenotype; Obesity; Multiple comparisons problem; Haplotype; Genetic association; Biology; Medicine; Internal medicine; Genetics; Gene; Oncology; Genotype; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004782778,0.00008738194,0.0001701804,0.00002166184,0.00005819655,0.00000517351,0.00007304561,0.0001015752,0.000005825874],"category_scores_gemma":[0.0004757192,0.00006956549,0.00002590123,0.00005373063,0.00006575036,0.000002541647,0.00007366883,0.00006794604,0.000001465217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000047283,"about_ca_system_score_gemma":0.00001427127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009996552,"about_ca_topic_score_gemma":0.00006357561,"domain_scores_codex":[0.9990631,0.00031022,0.0001778045,0.0001544097,0.00008599814,0.0002084354],"domain_scores_gemma":[0.9995182,0.00005205881,0.0001232903,0.0001890965,0.00003704314,0.00008030773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000111059,0.0004768748,0.9807574,0.000006766169,0.0002122629,4.360012e-7,0.0001072806,0.000004727079,0.01820242,0.000008602502,0.00006725867,0.0001448683],"study_design_scores_gemma":[0.0002963195,0.00006319072,0.9962199,0.00000848146,0.0003374001,7.949053e-7,0.000033775,0.0001585358,0.002611021,0.0001768852,0.00001418196,0.00007954649],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928432,0.006691559,0.00004419824,0.0001071959,0.00001480736,0.0001742572,0.00006017599,0.000002569491,0.00006202649],"genre_scores_gemma":[0.9957034,0.002912565,0.001109153,0.0001158935,0.00008063248,0.0000170216,0.00003460304,0.000007660183,0.00001905473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0155914,"threshold_uncertainty_score":0.2836798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02780799098985166,"score_gpt":0.2370846780116934,"score_spread":0.2092766870218418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}