{"id":"W2056742992","doi":"10.3899/jrheum.090696","title":"Variable Effects of 3 Different Chondroitin Sulfate Compounds on Human Osteoarthritic Cartilage/Chondrocytes: Relevance of Purity and Production Process","year":2010,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arthritis Research Centre of Canada; Hôpital Notre-Dame","funders":"","keywords":"Osteoarthritis; Cartilage; Chondroitin sulfate; Medicine; Proinflammatory cytokine; Aggrecan; Type II collagen; Matrix metalloproteinase; Interleukin; Catabolism; Endocrinology; Internal medicine; Molecular biology; Biochemistry; Andrology; Glycosaminoglycan; Metabolism; Chemistry; Inflammation; Cytokine; Biology; Pathology; Anatomy; Articular cartilage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005649484,0.0005618233,0.0002883254,0.000318499,0.0002098577,0.0004109807,0.0001840689,0.0004129459,0.0007526116],"category_scores_gemma":[0.0005547577,0.0001760048,0.0004382156,0.0003268624,0.0003671414,0.0002439393,0.000238132,0.0003553866,0.0001560505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002796497,"about_ca_system_score_gemma":0.0003053088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001139879,"about_ca_topic_score_gemma":0.002193774,"domain_scores_codex":[0.9993091,0.0002571275,0.0001029321,0.00007646768,0.0001738256,0.00008058624],"domain_scores_gemma":[0.9994668,0.0001807959,0.0001195071,0.00004234915,0.0001125282,0.00007808881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001426998,0.0001069961,0.0007735969,0.0001353102,0.00003409361,0.00004037907,0.00004594666,0.0001020496,0.9952099,0.0000140021,0.00001432934,0.002096473],"study_design_scores_gemma":[0.00004411618,0.004532698,0.01055659,0.00001652526,0.00008038501,0.0001634064,0.00006343405,0.0002334318,0.9837124,0.00001133594,0.0005762514,0.000009503904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941548,0.004599297,0.0005449115,0.0000390487,0.00001788477,0.00004056143,0.0001304804,0.00001062132,0.0004624644],"genre_scores_gemma":[0.9959573,0.001690355,0.001462056,0.00006227098,0.00001865268,0.00003292402,0.0003221929,0.000006602072,0.0004475725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001139879,"threshold_uncertainty_score":0.002987742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00828406984373343,"score_gpt":0.2570492176968407,"score_spread":0.2487651478531073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}