{"id":"W2056774854","doi":"10.1016/j.ymthe.2004.01.013","title":"Liver-Directed Adenoviral Gene Transfer in Murine Succinate Semialdehyde Dehydrogenase Deficiency","year":2004,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Intraperitoneal injection; Viral vector; Pharmacology; Enzyme; Genetic enhancement; Biology; Internal medicine; Endocrinology; Medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003422631,0.0006613201,0.00033845,0.0004957625,0.0001915418,0.0003262967,0.000444417,0.0006904004,0.001253665],"category_scores_gemma":[0.000158443,0.0002564831,0.0004612008,0.0002401407,0.000470894,0.0003191035,0.0003248701,0.0009940388,0.0004758557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003946663,"about_ca_system_score_gemma":0.0003307541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008556014,"about_ca_topic_score_gemma":0.0007816759,"domain_scores_codex":[0.9996985,0.00007452843,0.0000418339,0.00006418469,0.00004785365,0.00007309396],"domain_scores_gemma":[0.9997972,0.00005227111,0.000062775,0.00002588289,0.00001005335,0.00005193204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004543827,0.0001895922,0.000142039,0.00006530166,0.000008794135,0.000114964,0.00003618924,0.0002583512,0.9962028,0.000282839,0.00007029255,0.002174517],"study_design_scores_gemma":[0.0001916193,0.002623254,0.001031612,0.0000181723,0.00003747781,0.0004123171,0.00003948883,0.0012658,0.9917671,0.00007236524,0.002530539,0.00001016733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894329,0.001866921,0.005543626,0.0001518403,0.0001011805,0.0002728719,0.0009462172,0.0001921767,0.001492344],"genre_scores_gemma":[0.9860867,0.001823154,0.007624684,0.00005997413,0.00002329952,0.0001936251,0.0008826499,0.0000417357,0.003264206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001253665,"threshold_uncertainty_score":0.004193902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01217143281804496,"score_gpt":0.2636234640810409,"score_spread":0.2514520312629959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}