{"id":"W2056806024","doi":"10.1242/dev.02853","title":"<i>Drosophila</i>Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation","year":2007,"lang":"en","type":"article","venue":"Development","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Biology; Phosphorylation; Wnt signaling pathway; Cell biology; Signal transduction; SMAD; Nuclear export signal; Bone morphogenetic protein; Kinase; Protein-Serine-Threonine Kinases; Serine; Signal transducing adaptor protein; Protein kinase A; Genetics; Gene; Cell nucleus; Nucleus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002360474,0.00008497018,0.00009937498,0.00005312921,0.00003098216,0.000005340172,0.00003977177,0.00008042595,0.00001081987],"category_scores_gemma":[0.00003585504,0.00009380809,0.00001869612,0.00007242878,0.00002843429,0.000006273182,0.00003974848,0.00002872655,0.000001190859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001818286,"about_ca_system_score_gemma":0.00004270322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003634582,"about_ca_topic_score_gemma":0.000004943777,"domain_scores_codex":[0.9992554,0.00001453379,0.0003244949,0.0001676448,0.0001259861,0.0001119429],"domain_scores_gemma":[0.9996807,0.00001312213,0.0001353996,0.00007327983,0.00006263235,0.0000348749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001083877,0.00006293972,0.007753473,0.00006135691,0.00001277531,8.020308e-7,0.0002339016,0.0001374169,0.9884014,0.0000237137,0.00005156613,0.003152227],"study_design_scores_gemma":[0.000385777,0.00003515317,0.0378604,0.0000664471,0.000004832497,7.175398e-7,0.00005312678,0.0000450645,0.9600855,0.00001834187,0.001347427,0.0000971867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978621,0.00102732,0.0008415022,0.00001100153,0.00002817129,0.0001245747,0.000007187953,0.000005995387,0.00009217557],"genre_scores_gemma":[0.9969317,0.00005421324,0.002765788,0.00003379294,0.00001915526,0.000002685765,0.0001626762,0.00001215421,0.00001787102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03010693,"threshold_uncertainty_score":0.3825383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0142490907790073,"score_gpt":0.2554247334744689,"score_spread":0.2411756426954616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}