{"id":"W2056809624","doi":"10.1182/blood-2014-10-609271","title":"Thymic expression of a T-cell receptor targeting a tumor-associated antigen coexpressed in the thymus induces T-ALL","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"National Cancer Institute; National Institutes of Health","keywords":"T-cell receptor; Thymocyte; Biology; Cancer research; Receptor; Transgene; Signal transduction; Immunology; Survivin; Antigen; T cell; Cell biology; Molecular biology; Cancer; Gene; Genetics; CD8; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001533217,0.0003117405,0.0002219962,0.0002719808,0.0001240466,0.0005002426,0.0002220926,0.0002534993,0.001392715],"category_scores_gemma":[0.0001582273,0.0001760693,0.0002338074,0.0001325875,0.0001623539,0.0002166298,0.0002458985,0.0007586997,0.0005255663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002917709,"about_ca_system_score_gemma":0.0001783585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002769883,"about_ca_topic_score_gemma":0.0004946117,"domain_scores_codex":[0.999718,0.00003846358,0.00003315106,0.00006813271,0.00005838241,0.00008381434],"domain_scores_gemma":[0.9997438,0.00004467634,0.00007289336,0.00004382013,0.00001898938,0.00007584656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002678658,0.00001622284,0.0001472039,0.00001006484,0.000002679121,0.00003175608,0.000005986454,0.00002382011,0.9992481,0.00005253813,0.000009098485,0.0004258439],"study_design_scores_gemma":[0.00001609678,0.0003142479,0.002512237,0.000005021663,0.00002286482,0.0004210063,0.00002131122,0.0005534106,0.9941619,0.00002598974,0.001943389,0.000002443888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946269,0.0007049934,0.00285535,0.00004680596,0.00002180521,0.00004141665,0.0002438164,0.0001305761,0.001328326],"genre_scores_gemma":[0.995972,0.0003750809,0.001339216,0.00003205675,0.000007405942,0.00002158834,0.0003018289,0.00003410084,0.001916747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001392715,"threshold_uncertainty_score":0.004659116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04458352362943507,"score_gpt":0.3033461817699167,"score_spread":0.2587626581404816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}