{"id":"W2056867349","doi":"10.1517/14712598.2.7.751","title":"HIV-1 drug resistance: can we overcome?","year":2002,"lang":"en","type":"review","venue":"Expert Opinion on Biological Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Reverse transcriptase; Drug resistance; Drug; Nucleoside Reverse Transcriptase Inhibitor; Virology; Protease; Protease inhibitor (pharmacology); Biology; HIV drug resistance; Medicine; Human immunodeficiency virus (HIV); Immunology; Antiretroviral therapy; Viral load; Pharmacology; Genetics; Enzyme; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001799428,0.0008304553,0.002254195,0.0002143582,0.0001539908,0.00003215118,0.0002941279,0.0005847736,0.002421535],"category_scores_gemma":[0.00003857373,0.0004380668,0.0008343321,0.0003592783,0.0001275499,0.00002175669,0.00004986967,0.0005249066,0.001035712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003843825,"about_ca_system_score_gemma":0.0001299191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001596838,"about_ca_topic_score_gemma":6.837246e-7,"domain_scores_codex":[0.9971592,0.0003302789,0.0007129713,0.0008968398,0.000386785,0.0005138997],"domain_scores_gemma":[0.9984788,0.0003130123,0.000245829,0.0006386776,0.00004309249,0.0002806233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001226419,0.0005526861,0.00001293125,0.0001507458,0.0003211161,0.00005489223,0.0002405825,6.498348e-9,8.377569e-7,0.00038679,0.1710332,0.8271235],"study_design_scores_gemma":[0.001299686,0.0001561474,0.000006255992,0.00700847,0.000004438394,0.00002303899,0.00002638602,2.167101e-7,0.000007997826,0.00006684454,0.990898,0.0005025862],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000003304125,0.9824016,0.000003254858,0.01005878,0.0006826554,0.001403553,0.00005282263,0.0002142055,0.005179789],"genre_scores_gemma":[0.000003034628,0.9573358,0.0005592253,0.001038072,0.0008363316,0.0005041393,0.001007658,0.00006680726,0.03864893],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8266209,"threshold_uncertainty_score":0.9998071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1540583761806159,"score_gpt":0.3821740819905895,"score_spread":0.2281157058099736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}