{"id":"W2056894517","doi":"10.1006/jmcc.2000.1150","title":"A Farnesyltransferase Inhibitor Attenuates Cardiac Myocyte Hypertrophy and Gene Expression","year":2000,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"Endocrinology; Internal medicine; Farnesyltransferase; Farnesyltransferase inhibitor; Endothelin 1; Norepinephrine; Myocyte; Biology; MEK inhibitor; MAPK/ERK pathway; Chemistry; Kinase; Medicine; Prenylation; Cell biology; Biochemistry; Receptor; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002880101,0.000207324,0.0004109677,0.00005296399,0.00007400069,0.00002418461,0.0001271976,0.0002091549,0.0000144377],"category_scores_gemma":[0.00004965121,0.0001790019,0.0002852195,0.00005011858,0.0001689529,0.000006759327,0.00005101257,0.0001688688,0.000002414559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007864484,"about_ca_system_score_gemma":0.00005634836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002320939,"about_ca_topic_score_gemma":9.287211e-8,"domain_scores_codex":[0.9986969,0.0002831148,0.0003245938,0.0002987667,0.0001595666,0.0002370744],"domain_scores_gemma":[0.9993299,0.00001777555,0.00008604463,0.000244615,0.0001033599,0.0002182837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000354197,0.00002588927,0.001483416,0.00001715242,0.0001809191,0.000428669,0.00003363288,0.0001852569,0.9932083,0.000005427296,0.0002969051,0.003780251],"study_design_scores_gemma":[0.0009360679,0.0005027336,0.0002845869,0.0000229241,0.0001390282,0.0005359019,0.00003797304,0.000005514295,0.9871824,0.00007452277,0.01007352,0.0002048343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685749,0.02904407,0.001828988,0.00008169027,0.0001860878,0.0000990571,0.00002052576,0.000005374095,0.0001593467],"genre_scores_gemma":[0.9967332,0.001682051,0.0007064355,0.0002244259,0.0005346896,0.000005440538,0.00002773629,0.00003005581,0.00005592359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02815838,"threshold_uncertainty_score":0.7299485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004978448003956132,"score_gpt":0.1961213475569354,"score_spread":0.1911428995529793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}