{"id":"W2056894517","doi":"10.1006/jmcc.2000.1150","title":"A Farnesyltransferase Inhibitor Attenuates Cardiac Myocyte Hypertrophy and Gene Expression","year":2000,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"Endocrinology; Internal medicine; Farnesyltransferase; Farnesyltransferase inhibitor; Endothelin 1; Norepinephrine; Myocyte; Biology; MEK inhibitor; MAPK/ERK pathway; Chemistry; Kinase; Medicine; Prenylation; Cell biology; Biochemistry; Receptor; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000498073,0.0009985836,0.001330153,0.0006200431,0.0005644869,0.0007233505,0.0007618353,0.000875411,0.003434569],"category_scores_gemma":[0.0004346202,0.0005861505,0.0006178216,0.0003963061,0.0009843253,0.0006575976,0.0003315478,0.002457667,0.0007340246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000716169,"about_ca_system_score_gemma":0.001338609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001502139,"about_ca_topic_score_gemma":0.003458071,"domain_scores_codex":[0.9996057,0.00005808259,0.000043489,0.00007350202,0.00006389457,0.0001553873],"domain_scores_gemma":[0.9994895,0.0001129797,0.00008606914,0.00006416264,0.00003512893,0.0002121643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004863028,0.0005882308,0.0001268652,0.00008749105,0.00004352163,0.00009917554,0.00003582963,0.0002052205,0.9909793,0.0003170858,0.0002802403,0.002374188],"study_design_scores_gemma":[0.001100544,0.003103727,0.002613724,0.00001414406,0.0001043942,0.0001803629,0.00009430796,0.001212005,0.9893652,0.0001321974,0.002061287,0.0000181172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867208,0.00313189,0.003978595,0.0008522851,0.0004289816,0.0001335235,0.001036212,0.0003797899,0.003337948],"genre_scores_gemma":[0.9860001,0.002212581,0.00329984,0.0002929464,0.0001787824,0.0001899597,0.001179838,0.00008665098,0.006559215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003434569,"threshold_uncertainty_score":0.01148975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004978448003956132,"score_gpt":0.1961213475569354,"score_spread":0.1911428995529793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}