{"id":"W2056907950","doi":"10.1126/science.1156037","title":"Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3β Inactivation","year":2008,"lang":"en","type":"article","venue":"Science","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":469,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases","keywords":"GSK-3; Phosphorylation; Protein kinase B; Cell biology; MAPK/ERK pathway; p38 mitogen-activated protein kinases; Protein kinase A; GSK3B; Kinase; Substrate-level phosphorylation; Chemistry; Catenin; Biology; Signal transduction; Wnt signaling pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002950558,0.0007165058,0.0001792799,0.0003313775,0.0003015912,0.0004729768,0.0002778457,0.0003049315,0.003433237],"category_scores_gemma":[0.000199163,0.0001810405,0.0003579852,0.0002048053,0.0003120007,0.0005753433,0.0003552822,0.000677733,0.0008364987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004012845,"about_ca_system_score_gemma":0.0003244389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002343998,"about_ca_topic_score_gemma":0.0003907145,"domain_scores_codex":[0.9998248,0.00002710972,0.00001291477,0.00003894619,0.00004716571,0.00004903168],"domain_scores_gemma":[0.9999287,0.000009945109,0.0000217483,0.00001188804,0.00001125671,0.00001651596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002978022,0.00005673684,0.0005511159,0.0001490208,0.00001114857,0.000549554,0.00005418128,0.0001116932,0.9880485,0.00182399,0.0003292857,0.008016957],"study_design_scores_gemma":[0.0001041906,0.0003648955,0.004509366,0.00002489485,0.00002881919,0.002112976,0.00006228621,0.001542207,0.9759651,0.001858129,0.0134117,0.00001540169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9520358,0.01438641,0.01962552,0.0009200184,0.0003754352,0.0001012142,0.0004690948,0.0004525314,0.01163398],"genre_scores_gemma":[0.9867231,0.003431519,0.004640521,0.00008032381,0.00005891335,0.00007057362,0.0002843995,0.00002098261,0.004689618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003433237,"threshold_uncertainty_score":0.01148528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01634699109818106,"score_gpt":0.270976380284699,"score_spread":0.254629389186518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}