{"id":"W2056909832","doi":"10.1021/bi049145z","title":"Lipid Modulation of the Activity of Diacylglycerol Kinase α- and ζ-Isoforms:  Activation by Phosphatidylethanolamine and Cholesterol","year":2004,"lang":"en","type":"article","venue":"Biochemistry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Diacylglycerol kinase; Phosphatidylethanolamine; Phosphatidylserine; Biochemistry; Recoverin; Chemistry; Enzyme; Liposome; C2 domain; Gene isoform; Protein kinase C; Enzyme activator; Sphingomyelin; Cell biology; Phospholipid; Biology; Membrane; Phosphatidylcholine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001234046,0.0003059854,0.0001472471,0.0001391053,0.0000871776,0.0002910186,0.0001446346,0.0001381643,0.0009093622],"category_scores_gemma":[0.0001084934,0.0001210658,0.000220056,0.000150363,0.0001479363,0.0002437894,0.0001754484,0.000390403,0.0003555884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003908059,"about_ca_system_score_gemma":0.0001550903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006229669,"about_ca_topic_score_gemma":0.0006393946,"domain_scores_codex":[0.9998919,0.00001326081,0.0000134951,0.00002533055,0.00002544803,0.00003070049],"domain_scores_gemma":[0.9999074,0.00001487256,0.00002462259,0.00001506076,0.00001555085,0.00002255023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008111012,0.000007687371,0.0001074649,0.000008120117,0.000001575134,0.000009051616,0.000004405314,0.00001116709,0.9994535,0.0000277896,0.00000456095,0.0002836237],"study_design_scores_gemma":[0.00001163227,0.00003726599,0.002892803,0.000001949007,0.000006931195,0.00006616193,0.00001558512,0.0004102263,0.9960209,0.00002627121,0.0005078652,0.000002564266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966208,0.0009631352,0.001364827,0.0000781095,0.00001869172,0.00001423913,0.0002512984,0.00002029786,0.0006686051],"genre_scores_gemma":[0.9955153,0.0007319385,0.0009167525,0.00002450602,0.000004994261,0.00001809254,0.000467228,0.00001303826,0.002308224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009093622,"threshold_uncertainty_score":0.003042102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006262792251567807,"score_gpt":0.2154765599303249,"score_spread":0.2092137676787571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}