{"id":"W2056920544","doi":"10.1182/blood-2011-06-363911","title":"Bortezomib-induced “BRCAness” sensitizes multiple myeloma cells to PARP inhibitors","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Calgary","funders":"National Cancer Institute; Geoffrey Beene Cancer Research Center; Multiple Myeloma Research Foundation","keywords":"Bortezomib; RAD51; Poly ADP ribose polymerase; Genome instability; PARP1; DNA repair; DNA damage; Homologous recombination; Biology; Proteasome inhibitor; Proteasome; Synthetic lethality; Molecular biology; Cancer research; Ubiquitin; PARP inhibitor; Multiple myeloma; DNA; Cell biology; Polymerase; Genetics; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000128691,0.0002036967,0.0001676359,0.0000486957,0.00006123438,0.0000159966,0.0001891964,0.0001899925,0.0000310688],"category_scores_gemma":[0.00006393122,0.0002045911,0.0001067833,0.00009232213,0.00002253701,0.000003290212,0.0001701727,0.00007195079,0.0001352299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006691658,"about_ca_system_score_gemma":0.00005211355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007095129,"about_ca_topic_score_gemma":0.00007448557,"domain_scores_codex":[0.9988003,0.0000503522,0.0002065124,0.0004571537,0.0001377557,0.0003478809],"domain_scores_gemma":[0.9991329,0.000008526514,0.00006230547,0.000523932,0.00007555795,0.0001968159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004660014,0.0002077356,0.0009420775,0.000008782579,0.00005997054,0.00004089127,0.0001860609,0.00000134006,0.9970331,0.0000207489,0.0006449705,0.000807756],"study_design_scores_gemma":[0.0008862235,0.0003979938,0.001333342,0.00001152607,0.00004170937,0.00002882914,0.000150985,0.000006678032,0.9941683,0.00002991089,0.002661335,0.0002832141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968777,0.00005170299,0.0001509518,0.00002478341,0.0003825305,0.0002825833,0.00001785276,0.00006205707,0.002149838],"genre_scores_gemma":[0.993614,0.000007824517,0.005190519,0.000323083,0.000313209,0.00003422594,0.00002636639,0.00004607182,0.0004447325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005039568,"threshold_uncertainty_score":0.8342984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426151039658454,"score_gpt":0.2086126622192225,"score_spread":0.194351151822638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}