{"id":"W2056920544","doi":"10.1182/blood-2011-06-363911","title":"Bortezomib-induced “BRCAness” sensitizes multiple myeloma cells to PARP inhibitors","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Calgary","funders":"National Cancer Institute; Geoffrey Beene Cancer Research Center; Multiple Myeloma Research Foundation","keywords":"Bortezomib; RAD51; Poly ADP ribose polymerase; Genome instability; PARP1; DNA repair; DNA damage; Homologous recombination; Biology; Proteasome inhibitor; Proteasome; Synthetic lethality; Molecular biology; Cancer research; Ubiquitin; PARP inhibitor; Multiple myeloma; DNA; Cell biology; Polymerase; Genetics; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007563424,0.0002601768,0.0003685672,0.0001397402,0.00009578886,0.0001926233,0.0001630735,0.0001639053,0.001490478],"category_scores_gemma":[0.00006342529,0.0001527239,0.0001948451,0.000172387,0.00007673794,0.0001140732,0.0001383358,0.000585862,0.0002905606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002630885,"about_ca_system_score_gemma":0.000146975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005118035,"about_ca_topic_score_gemma":0.001087442,"domain_scores_codex":[0.9998971,0.00001142987,0.00001314665,0.00002305954,0.00003121431,0.00002408812],"domain_scores_gemma":[0.9999487,0.00000745747,0.00001548136,0.00001112316,0.00000596518,0.00001127934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001194932,0.00005142151,0.0003068831,0.00005080964,0.00001418556,0.00006715756,0.00001493192,0.000167327,0.9960862,0.00006260543,0.0001633971,0.002895641],"study_design_scores_gemma":[0.0000484632,0.0009159403,0.01327583,0.000007140105,0.00002142654,0.0006518188,0.00001564816,0.0007152721,0.9783677,0.00005973112,0.005914325,0.000006664666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917344,0.003122856,0.001369436,0.0001401632,0.00005229741,0.00005647515,0.0008823245,0.0002751448,0.002367018],"genre_scores_gemma":[0.9941092,0.001709803,0.001061379,0.0001203675,0.00001576227,0.00004546785,0.001065502,0.0000193308,0.001853298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001490478,"threshold_uncertainty_score":0.004986107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426151039658454,"score_gpt":0.2086126622192225,"score_spread":0.194351151822638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}