{"id":"W2056935170","doi":"10.1210/me.2005-0111","title":"CHIP (Carboxyl Terminus of Hsc70-Interacting Protein) Promotes Basal and Geldanamycin-Induced Degradation of Estrogen Receptor-α","year":2005,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"U.S. Army Medical Research Acquisition Activity; National Cancer Institute; University of North Carolina at Chapel Hill; School of Medicine, Indiana University; Tsinghua University; York University","keywords":"Biology; Estrogen receptor; Geldanamycin; Estrogen receptor alpha; Hsp90; Cell biology; Ubiquitin ligase; Transactivation; Ubiquitin; Estrogen receptor beta; Transfection; Protein degradation; MG132; Molecular biology; Cancer research; Heat shock protein; Gene expression; Proteasome; Proteasome inhibitor; Biochemistry; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001458128,0.0003715717,0.0002614405,0.0002580069,0.000115047,0.0001817663,0.0001517283,0.0001537955,0.001349848],"category_scores_gemma":[0.00009926644,0.0001450602,0.0003046267,0.0001648934,0.0001932003,0.0000702928,0.0002404945,0.0003991975,0.0006398034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002967666,"about_ca_system_score_gemma":0.0002217441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006800516,"about_ca_topic_score_gemma":0.001506281,"domain_scores_codex":[0.9998492,0.0000238449,0.00001320739,0.00002798395,0.00004468664,0.00004101346],"domain_scores_gemma":[0.9998925,0.00001749698,0.00002595068,0.00001575343,0.00001219658,0.00003616089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008024878,0.00002393122,0.00007320412,0.00003463783,0.000006617526,0.00002337826,0.000008655849,0.00002895115,0.9987858,0.00003799577,0.00007746997,0.0008191361],"study_design_scores_gemma":[0.00001076766,0.0001977224,0.00572296,0.000005341331,0.000008745371,0.0001394404,0.000012567,0.0006455971,0.9903273,0.00002115382,0.002904682,0.000003818078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881655,0.003670102,0.003810583,0.0001696823,0.00007811948,0.00003845636,0.001095001,0.0004187916,0.002553769],"genre_scores_gemma":[0.9872155,0.001509693,0.003297513,0.0001409564,0.00001719098,0.00007917352,0.002485765,0.00005109585,0.005203076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001349848,"threshold_uncertainty_score":0.004515648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01504410784509412,"score_gpt":0.2834082126453615,"score_spread":0.2683641048002674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}