{"id":"W2056935170","doi":"10.1210/me.2005-0111","title":"CHIP (Carboxyl Terminus of Hsc70-Interacting Protein) Promotes Basal and Geldanamycin-Induced Degradation of Estrogen Receptor-α","year":2005,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"U.S. Army Medical Research Acquisition Activity; National Cancer Institute; University of North Carolina at Chapel Hill; School of Medicine, Indiana University; Tsinghua University; York University","keywords":"Biology; Estrogen receptor; Geldanamycin; Estrogen receptor alpha; Hsp90; Cell biology; Ubiquitin ligase; Transactivation; Ubiquitin; Estrogen receptor beta; Transfection; Protein degradation; MG132; Molecular biology; Cancer research; Heat shock protein; Gene expression; Proteasome; Proteasome inhibitor; Biochemistry; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001633451,0.0002055556,0.000295976,0.0001500496,0.00004672355,0.00001063088,0.000251045,0.0001709995,0.00002833136],"category_scores_gemma":[0.0004711161,0.0002100527,0.00009449901,0.000115761,0.0001392886,0.00001054766,0.0002700264,0.0002057823,0.000005262501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000249797,"about_ca_system_score_gemma":0.0001247376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001342817,"about_ca_topic_score_gemma":0.00003069068,"domain_scores_codex":[0.9982457,0.0002227264,0.0004227062,0.0004519617,0.0002036558,0.0004532723],"domain_scores_gemma":[0.9990829,0.00002332638,0.0001686811,0.0004659896,0.0001643071,0.00009475279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001100668,0.00009333791,0.001074928,0.00006652937,0.00008846637,0.00001912281,0.00003670591,0.000008636508,0.9743687,0.000240116,0.00002050103,0.02387288],"study_design_scores_gemma":[0.0006558826,0.0007470284,0.0003781344,0.0000362173,0.00001492764,0.0000843864,0.00003517942,0.0001425975,0.9961331,0.0000361393,0.001569692,0.0001666373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997012,0.0005572397,0.0007266292,0.0004341292,0.00004539459,0.0006732023,0.00001229874,0.00001382088,0.0005253503],"genre_scores_gemma":[0.9936791,0.00003062993,0.005838245,0.00004368327,0.0000887859,0.00008379898,0.00005171946,0.00003674298,0.0001472641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02370624,"threshold_uncertainty_score":0.85657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01504410784509412,"score_gpt":0.2834082126453615,"score_spread":0.2683641048002674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}