{"id":"W2056954418","doi":"10.1007/s40262-014-0152-3","title":"A Comprehensive Review on the Pharmacokinetics of Antibiotics in Interstitial Fluid Spaces in Humans: Implications on Dosing and Clinical Pharmacokinetic Monitoring","year":2014,"lang":"en","type":"review","venue":"Clinical Pharmacokinetics","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's & Women's Health Centre of British Columbia; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Pharmacokinetics; Piperacillin; Dosing; Pharmacology; Medicine; Antibiotics; Volume of distribution; Distribution (mathematics); Intensive care medicine; Internal medicine; Biology; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00103955,0.001033343,0.002558547,0.002486989,0.0002025929,0.001343905,0.0008838767,0.001125503,0.003273815],"category_scores_gemma":[0.001805679,0.0003753261,0.001234156,0.002565098,0.0003705021,0.001435306,0.0006899399,0.00158799,0.001067424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000582845,"about_ca_system_score_gemma":0.002119366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00149515,"about_ca_topic_score_gemma":0.002527323,"domain_scores_codex":[0.9995345,0.0001022403,0.0001175145,0.00006380082,0.0001553995,0.00002661019],"domain_scores_gemma":[0.9990865,0.0005275246,0.0001690902,0.00001628343,0.0001676782,0.00003290658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001872589,0.00009269438,0.0002204369,0.08159081,0.0003343314,0.0001925158,0.00006548664,0.0004470851,0.002169192,0.001600553,0.02711255,0.885987],"study_design_scores_gemma":[0.00006606249,0.0002908554,0.001666356,0.02037268,0.001041635,0.001581085,0.00009659046,0.0001972606,0.0009370127,0.001432634,0.9722577,0.00006023697],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000672319,0.9993461,0.00009265278,0.0001289079,0.00008368038,0.000005466058,0.00003152761,0.000003731173,0.0002407263],"genre_scores_gemma":[0.0003404137,0.9990622,0.000212076,0.0001323941,0.00007744916,0.000005864695,0.00002807324,8.918714e-7,0.0001406935],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003273815,"threshold_uncertainty_score":0.010952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2205027227140201,"score_gpt":0.5156797864411059,"score_spread":0.2951770637270858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}