{"id":"W2056987772","doi":"10.1016/j.bmcl.2014.09.037","title":"Inhibition of the ANT(2″)-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Aminoglycoside; Chemistry; Bacteria; ANT; Gentamicin; Enzyme; Antibiotics; Microbiology; Biochemistry; Stereochemistry; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008891679,0.0002600691,0.0001555727,0.0001157222,0.00006423085,0.0002236988,0.0002799709,0.0002271454,0.0009832934],"category_scores_gemma":[0.0001645502,0.000139932,0.000159995,0.00009098068,0.0001939796,0.0001337401,0.0001470154,0.0004617194,0.0004677298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001482334,"about_ca_system_score_gemma":0.0001650517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004459422,"about_ca_topic_score_gemma":0.0003755146,"domain_scores_codex":[0.9999058,0.00001653058,0.00001617937,0.00001220314,0.00002210779,0.0000271373],"domain_scores_gemma":[0.9998658,0.00002996409,0.00003924435,0.00002543523,0.00001063724,0.00002903612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001721026,0.00002147102,0.00006845303,0.00001510081,0.000002400613,0.00006775722,0.000008218708,0.00009102241,0.9985462,0.00009316086,0.00002637187,0.000887687],"study_design_scores_gemma":[0.00001030505,0.0001039886,0.0004162913,0.000001492953,0.00000282596,0.00008155898,0.000006859377,0.0002823229,0.9983749,0.00001818283,0.0006994326,0.000001749843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948351,0.0006766948,0.001994961,0.00009777586,0.00003410691,0.00002412861,0.0003294747,0.0001307438,0.001876983],"genre_scores_gemma":[0.9962106,0.0003380491,0.00127573,0.00002729187,0.000005701623,0.00001309854,0.0003037078,0.0000197437,0.001806075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009832934,"threshold_uncertainty_score":0.003289461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003995082417266565,"score_gpt":0.208675049122543,"score_spread":0.2046799667052764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}