{"id":"W2057000168","doi":"10.1021/cc070042k","title":"Controlled Peptide Solvation in Portion-Mixing Libraries of FRET Peptides:  Improved Specificity Determination for Dengue 2 Virus NS2B-NS3 Protease and Human Cathepsin S","year":2007,"lang":"en","type":"article","venue":"Journal of Combinatorial Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"NS3; Dengue fever; Protease; Peptide; Chemistry; Förster resonance energy transfer; Dengue virus; Virology; Cathepsin B; Biochemistry; Molecular biology; Biology; Enzyme; Fluorescence; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009321147,0.0001482081,0.0003707888,0.0000796364,0.00006542051,0.00002842942,0.0001110448,0.0002115303,0.000001026329],"category_scores_gemma":[0.0005155187,0.0001343359,0.0001609945,0.00009120122,0.00009704848,0.00002534908,0.00003243196,0.0001488459,1.529862e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004099344,"about_ca_system_score_gemma":0.0000836499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001242975,"about_ca_topic_score_gemma":0.00001023743,"domain_scores_codex":[0.9987151,0.00002953821,0.0007716432,0.0001702974,0.000154963,0.000158459],"domain_scores_gemma":[0.9984299,0.00006174712,0.0009059872,0.0001374748,0.0003983089,0.00006661413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001029127,0.0001517059,0.002055684,0.00006647539,0.00003739828,0.00000474321,0.00002918081,0.00000140052,0.9959618,0.00009096734,0.00004449314,0.0005269572],"study_design_scores_gemma":[0.003335819,0.0002819916,0.0009205231,0.00007472912,0.00005351169,0.00001847514,0.00009741783,0.00004007445,0.9908233,0.004062604,0.0001530796,0.0001384446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950171,0.0001292938,0.00437568,0.00003778149,0.0001046164,0.0002528373,0.000008603743,0.000006758516,0.00006733125],"genre_scores_gemma":[0.9947493,0.00003371428,0.004620699,0.00001045867,0.000482169,0.000005534066,0.00003288916,0.00001396649,0.00005125972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005138537,"threshold_uncertainty_score":0.5478058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00825666996213272,"score_gpt":0.273367232110156,"score_spread":0.2651105621480233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}