{"id":"W2057014824","doi":"10.1016/j.brainres.2007.11.063","title":"Beneficial effect of dipyridyl, a liposoluble iron chelator against focal cerebral ischemia: In vivo and in vitro evidence of protection of cerebral endothelial cells","year":2008,"lang":"en","type":"article","venue":"Brain Research","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences","funders":"","keywords":"Neuroprotection; In vivo; Ischemia; Pharmacology; Blood–brain barrier; Superoxide dismutase; Chemistry; Brain damage; In vitro; Superoxide; Intracellular; Heme oxygenase; Brain ischemia; Oxidative stress; Medicine; Biochemistry; Heme; Central nervous system; Biology; Internal medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791871,0.0005849483,0.0006290067,0.0002526515,0.0002146107,0.0002272147,0.0003125324,0.0005362422,0.001622595],"category_scores_gemma":[0.000205259,0.000203406,0.0002041231,0.0001569252,0.0003390152,0.0003464674,0.0001586822,0.0006338744,0.000245461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001501869,"about_ca_system_score_gemma":0.0003279808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006657705,"about_ca_topic_score_gemma":0.000535253,"domain_scores_codex":[0.9999447,0.00001417464,0.00000478729,0.00001041365,0.000004758886,0.00002117156],"domain_scores_gemma":[0.9998807,0.00002616351,0.00002236087,0.00002180663,0.00000928899,0.00003963369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0134889,0.0004282676,0.0001350209,0.0002144085,0.00004481044,0.0003503876,0.00003631332,0.00008355501,0.9771014,0.0001664856,0.0003043399,0.007646019],"study_design_scores_gemma":[0.001182424,0.00696146,0.002060951,0.00001447503,0.0001694397,0.0005866542,0.0000296261,0.000543494,0.9867941,0.00009172947,0.001553667,0.0000120975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949176,0.002911485,0.0008009397,0.0001750461,0.00006564524,0.00002401628,0.0001631219,0.00008178124,0.0008604809],"genre_scores_gemma":[0.9951557,0.001930714,0.001031501,0.00009267911,0.00005361636,0.00002434978,0.0003075696,0.00001940619,0.00138449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001622595,"threshold_uncertainty_score":0.005428076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02752206863631982,"score_gpt":0.3027823478869109,"score_spread":0.2752602792505911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}