{"id":"W2057037460","doi":"10.1074/jbc.m502184200","title":"Cdk2-dependent Phosphorylation of Homeobox Transcription Factor CDX2 Regulates Its Nuclear Translocation and Proteasome-mediated Degradation in Human Intestinal Epithelial Cells","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; Université de Sherbrooke","funders":"","keywords":"CDX2; Cell biology; Cyclin-dependent kinase 2; Proteasome inhibitor; Transcription factor; Biology; Phosphorylation; Nuclear export signal; Nuclear transport; Molecular biology; Proteasome; Cancer research; Protein kinase A; Cell nucleus; Biochemistry; Cytoplasm; Homeobox","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003371869,0.0001329031,0.0002347387,0.00003387809,0.0000412712,0.00001028469,0.0001028097,0.0003318712,0.00003568896],"category_scores_gemma":[0.00009096604,0.0001011056,0.00007386091,0.00007561564,0.00007362162,0.00001563001,0.00001158708,0.0002363725,0.000001126193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003690007,"about_ca_system_score_gemma":0.0000483338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004187607,"about_ca_topic_score_gemma":0.000001762128,"domain_scores_codex":[0.9988466,0.00008678713,0.0006029616,0.0001816564,0.0001405075,0.0001415258],"domain_scores_gemma":[0.9992326,0.00001839376,0.0004133973,0.00006499391,0.0001685508,0.0001020679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002843086,0.0001323095,0.001314503,0.0000920325,0.00001889841,0.000001703687,0.0001284415,0.0001364763,0.9957947,0.000007181512,0.000007813587,0.002081608],"study_design_scores_gemma":[0.001064417,0.0005035083,0.008553465,0.000106267,0.00001040164,0.00003408534,0.0001186596,0.0001271887,0.9891022,0.00001547611,0.000251802,0.0001125514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981365,0.001140129,0.0002641138,0.0001584932,0.00003094752,0.0001728737,0.00002129241,0.000005461527,0.00007024701],"genre_scores_gemma":[0.9987657,0.0007365302,0.0002049841,0.00002644264,0.0001670904,0.000002419713,0.0000473389,0.000009245733,0.00004022563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007238962,"threshold_uncertainty_score":0.4122968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01699080101140572,"score_gpt":0.2471399165442599,"score_spread":0.2301491155328542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}