{"id":"W2057038995","doi":"10.1021/ja111138y","title":"Synthesis and Molecular Modeling Provide Insight into a <i>Pseudomonas aeruginosa</i> Quorum Sensing Conundrum","year":2011,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Calgary","keywords":"Quorum sensing; Pseudomonas aeruginosa; Chemistry; Homoserine; Bacteria; Molecule; Stereochemistry; Molecular model; Small molecule; Computational biology; Combinatorial chemistry; Biochemistry; Gene; Organic chemistry; Virulence","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002301551,0.000734646,0.0004471581,0.0001235028,0.0002885424,0.000483207,0.0005252969,0.0006469366,0.006915784],"category_scores_gemma":[0.0002557998,0.0002954792,0.0004216028,0.0002301014,0.0001563724,0.000847586,0.0002451871,0.0009594059,0.002324812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003405727,"about_ca_system_score_gemma":0.0007462668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001307927,"about_ca_topic_score_gemma":0.002431312,"domain_scores_codex":[0.9999223,0.00001826171,0.000003566656,0.00001272959,0.00002531944,0.00001792196],"domain_scores_gemma":[0.9999316,0.00002393759,0.00001161148,0.000009453433,0.00001234959,0.00001107606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0006325525,0.0006203305,0.002146383,0.002054183,0.0001110146,0.001607562,0.0004653755,0.208771,0.5635942,0.104505,0.01297777,0.1025146],"study_design_scores_gemma":[0.0004372901,0.001127409,0.001205302,0.0002202607,0.0001285855,0.0007144454,0.0004685174,0.5948573,0.2227454,0.02384451,0.1541297,0.0001213322],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6016583,0.01222484,0.2756609,0.006879355,0.0004913053,0.0003469535,0.005610366,0.002828178,0.09429964],"genre_scores_gemma":[0.7936281,0.01331869,0.1770115,0.0004533861,0.00005875803,0.0002587835,0.002356766,0.0004656493,0.01244844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006915784,"threshold_uncertainty_score":0.0231356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102043111189686,"score_gpt":0.2157334778824111,"score_spread":0.2055291667634425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}