{"id":"W2057068760","doi":"10.1097/mib.0000000000000264","title":"Validation of Gene Expression Biomarker Analysis for Biopsy-based Clinical Trials in Crohnʼs Disease","year":2015,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; University of California, San Diego; National Institutes of Health","keywords":"Crohn's disease; Medicine; Proinflammatory cytokine; Biopsy; Disease; Biomarker; Internal medicine; Real-time polymerase chain reaction; Gastroenterology; Gene expression; Pathology; Gene; Inflammation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.1976373,0.001361666,0.00227214,0.001455893,0.000711744,0.002138418,0.001687299,0.002504848,0.001926713],"category_scores_gemma":[0.1795906,0.0007042767,0.001519942,0.001606934,0.002872151,0.001059288,0.001206791,0.001618683,0.0009132009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001011833,"about_ca_system_score_gemma":0.002411049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002971026,"about_ca_topic_score_gemma":0.0003376472,"domain_scores_codex":[0.7903851,0.1780577,0.00829336,0.006354554,0.0157052,0.001204086],"domain_scores_gemma":[0.8068536,0.1274682,0.02460195,0.0173011,0.0219592,0.001815941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.08105696,0.004498438,0.3261091,0.008725824,0.006363335,0.0007614262,0.002216976,0.02028262,0.2481935,0.005373779,0.006908952,0.289509],"study_design_scores_gemma":[0.01725783,0.1392998,0.4787942,0.001950299,0.005106063,0.002364534,0.0007149022,0.0698738,0.2074305,0.009991207,0.06673256,0.0004843675],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.4718743,0.02097549,0.4671083,0.003568667,0.002037091,0.02255773,0.003113386,0.000881771,0.007883175],"genre_scores_gemma":[0.7907634,0.001760414,0.1794598,0.002753432,0.0005998142,0.02137165,0.002218752,0.0001886455,0.0008840976],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.1976373,"threshold_uncertainty_score":0.9894561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06688343490094568,"score_gpt":0.3624897331866605,"score_spread":0.2956062982857148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}