{"id":"W2057080045","doi":"10.1021/jm401090a","title":"Novel Carvedilol Analogues That Suppress Store-Overload-Induced Ca<sup>2+</sup>Release","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"National Heart, Lung, and Blood Institute","keywords":"Chemistry; Carvedilol; Endoplasmic reticulum; Linker; Ryanodine receptor 2; Calcium; HEK 293 cells; Calcium channel; Bioassay; Pharmacology; Biophysics; Biochemistry; Heart failure; Ryanodine receptor; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007631192,0.0002283477,0.0002886403,0.0001488581,0.00007029729,0.0002583074,0.0003176856,0.0001949867,0.0007562419],"category_scores_gemma":[0.00009300109,0.00008499175,0.0001638495,0.0001328769,0.0001527414,0.0001408678,0.0001235574,0.00048756,0.0003105631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002181301,"about_ca_system_score_gemma":0.0001577604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002249223,"about_ca_topic_score_gemma":0.0008540184,"domain_scores_codex":[0.9999617,0.000004516213,0.000004102963,0.000006291483,0.0000105604,0.00001282524],"domain_scores_gemma":[0.9999633,0.00000622405,0.000008267306,0.000003464411,0.000007483005,0.00001128426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006843755,0.0001704082,0.0002858897,0.0001558885,0.00001618672,0.0002104849,0.00004034859,0.0006013949,0.9732292,0.0004495751,0.0002226443,0.02393356],"study_design_scores_gemma":[0.0004946159,0.003634781,0.003520853,0.00002170183,0.00005968862,0.000977513,0.00005090032,0.001312514,0.9753761,0.0001141734,0.01441588,0.00002128509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986294,0.005160196,0.003660267,0.0001439929,0.00004291615,0.0001428658,0.0005231345,0.0001254065,0.003907126],"genre_scores_gemma":[0.9864981,0.00503375,0.004812321,0.0001745679,0.0000186823,0.00008097626,0.0009943304,0.00001486602,0.002372468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007562419,"threshold_uncertainty_score":0.00252986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01564361683067948,"score_gpt":0.2368225374610673,"score_spread":0.2211789206303878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}