{"id":"W2057082615","doi":"10.1021/jm031034v","title":"Structure−Activity Study of the ORL1 Antagonist Ac-Arg-d-Cha-Qaa-d-Arg-d-p-ClPhe-NH2","year":2004,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Antagonist; Receptor; Stereochemistry; Peptide; Nociceptin receptor; Biochemistry; Opioid peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002067836,0.0003577813,0.0005144674,0.0001212938,0.0001302191,0.0002788811,0.000381333,0.0003229949,0.001942289],"category_scores_gemma":[0.0002136362,0.0001829764,0.0002149939,0.000135595,0.0002462122,0.0001845059,0.0001247211,0.0005551383,0.0007429337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004379581,"about_ca_system_score_gemma":0.0003083737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007869911,"about_ca_topic_score_gemma":0.000973829,"domain_scores_codex":[0.9998941,0.00002276423,0.00000581481,0.00001833459,0.00002100081,0.00003790995],"domain_scores_gemma":[0.9999094,0.0000163114,0.00002811828,0.000007284529,0.00001307726,0.0000257775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000504368,0.00008889636,0.0001389931,0.00007227188,0.00001211488,0.00008263443,0.00002153624,0.0002635885,0.9965394,0.00006874779,0.00005898165,0.002148425],"study_design_scores_gemma":[0.0006146323,0.006307556,0.004484971,0.00001518772,0.00008447564,0.0009590231,0.00002576728,0.001881788,0.9796405,0.00004632602,0.005913238,0.00002655838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923462,0.002988101,0.001136152,0.000128576,0.00001649795,0.00008083935,0.0003713677,0.00004144397,0.002890787],"genre_scores_gemma":[0.9921616,0.001861431,0.001986474,0.00019694,0.00001785084,0.00005489026,0.001187894,0.00002106127,0.002511979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001942289,"threshold_uncertainty_score":0.006497562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01682000832396919,"score_gpt":0.2496255974732676,"score_spread":0.2328055891492984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}