{"id":"W2057128934","doi":"10.1158/1538-7445.am2013-267","title":"Abstract 267: MYC maintains the self-renewal of cancer stem cells through the regulation of the glutathione redox system.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"SOD2; Cancer stem cell; Glutathione; Stem cell; Cancer research; Biology; Downregulation and upregulation; Mitochondrial ROS; Superoxide dismutase; Chemistry; Mitochondrion; Cell biology; Oxidative stress; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007134196,0.0001193217,0.0002469957,0.0000722313,0.000337062,0.00003471757,0.0003755556,0.00008053073,0.000869146],"category_scores_gemma":[0.000039129,0.00005397043,0.0001586884,0.0006175381,0.000383539,0.00009677207,0.0001138589,0.0005631672,0.00002463226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004400492,"about_ca_system_score_gemma":0.000639475,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02641205,"about_ca_topic_score_gemma":0.0008863487,"domain_scores_codex":[0.9979195,0.0002267079,0.0004281454,0.0002172368,0.0008833784,0.0003250114],"domain_scores_gemma":[0.9976867,0.0003971531,0.0002202709,0.0007398591,0.0009000403,0.00005590536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001133043,0.00009981379,0.0006266545,0.000399808,0.0002777953,8.280477e-7,0.004563258,0.001090452,0.9728297,0.003588572,0.01462255,0.001787242],"study_design_scores_gemma":[0.0007894211,0.0001818955,0.05308199,0.001837973,0.0001935195,0.00001017819,0.01176941,0.001333359,0.9162519,0.0003089857,0.01411771,0.0001236693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844274,0.001001495,0.00001081674,0.008129755,0.0005210449,0.001411176,0.00008274866,0.00002740571,0.004388181],"genre_scores_gemma":[0.9973249,0.0003231887,0.00001819875,0.00009028291,0.0003707472,0.0003542351,0.000002984487,0.00002548694,0.001489921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05657783,"threshold_uncertainty_score":0.9800712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06550069837704849,"score_gpt":0.3763647384960248,"score_spread":0.3108640401189763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}