{"id":"W2057161704","doi":"10.1016/j.beem.2013.02.009","title":"The CASR gene: Alternative splicing and transcriptional control, and calcium-sensing receptor (CaSR) protein: Structure and ligand binding sites","year":2013,"lang":"en","type":"review","venue":"Best Practice & Research Clinical Endocrinology & Metabolism","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Royal Victoria Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Exon; Alternative splicing; Calcium-sensing receptor; Biology; RNA splicing; Intron; Coding region; Transmembrane domain; Signal peptide; Gene; Genetics; Cell biology; Peptide sequence; Chemistry; Calcium; RNA; Calcium metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006842962,0.0008142099,0.001311138,0.001733329,0.0002588715,0.001215358,0.001171885,0.00129864,0.001771659],"category_scores_gemma":[0.0007491719,0.0003562195,0.0004267681,0.001992322,0.001123598,0.001177951,0.0005850521,0.002054936,0.001457833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009832152,"about_ca_system_score_gemma":0.001399182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001799844,"about_ca_topic_score_gemma":0.00240227,"domain_scores_codex":[0.9997529,0.00002874168,0.00003807081,0.00006509735,0.00009318471,0.00002204004],"domain_scores_gemma":[0.9996262,0.0001721144,0.00007083618,0.000009550618,0.00008744698,0.00003391983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001376969,0.00006238762,0.0003509483,0.008491622,0.00006521378,0.0003539512,0.00004895787,0.0004822954,0.007201391,0.005191094,0.02765111,0.9499634],"study_design_scores_gemma":[0.00004108739,0.0001261774,0.001830516,0.001377444,0.0001182441,0.004464075,0.00008256459,0.0003535793,0.003488275,0.003331443,0.9847334,0.00005315186],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002040869,0.9982535,0.0003367823,0.0003478503,0.0001773908,0.000003739887,0.00001629075,0.000009293033,0.0006510612],"genre_scores_gemma":[0.001091407,0.9969583,0.0005090105,0.0002289037,0.0003580371,0.000006470594,0.00005183755,0.000002674415,0.0007933645],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001799844,"threshold_uncertainty_score":0.007133722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.229022043805113,"score_gpt":0.4791412628200888,"score_spread":0.2501192190149758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}