{"id":"W2057199764","doi":"10.1074/jbc.m100406200","title":"Residue Gly1326 of the N-type Calcium Channel α1B Subunit Controls Reversibility of ω-Conotoxin GVIA and MVIIA Block","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada","keywords":"Chemistry; Conotoxin; Calcium channel; Arginine; N-type calcium channel; Peptide; Amino acid; Mutant; Peptide sequence; Stereochemistry; Biophysics; Biochemistry; Calcium; Biology; T-type calcium channel; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416845,0.000297142,0.0002677339,0.0001203832,0.0001093302,0.0002200278,0.0001483351,0.0002528857,0.00178075],"category_scores_gemma":[0.0003073335,0.0001274595,0.0001701648,0.0001080073,0.0002257142,0.0001674899,0.0001449323,0.0003531513,0.0005898921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002175063,"about_ca_system_score_gemma":0.0001779963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003774597,"about_ca_topic_score_gemma":0.0004865334,"domain_scores_codex":[0.9998612,0.00002561596,0.00001853268,0.00002669984,0.00003669948,0.00003123029],"domain_scores_gemma":[0.9997662,0.00003760474,0.00008490521,0.00001628652,0.00001609922,0.00007904282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000179147,0.00002205563,0.0002637935,0.000009474172,0.000003066169,0.00005771362,0.000009055219,0.00004102723,0.9988106,0.00003896836,0.00001063113,0.0005543266],"study_design_scores_gemma":[0.00006491663,0.001023529,0.0154726,0.00001041573,0.00001731453,0.000837297,0.00003632731,0.001488085,0.9793571,0.00009430113,0.001586191,0.00001191347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998768,0.0002638695,0.0002792136,0.00002334941,0.00001377735,0.000008790796,0.00005000003,0.00002450454,0.0005684518],"genre_scores_gemma":[0.9989298,0.0001415556,0.0003262259,0.00002012993,0.000005115731,0.000006607456,0.00009311323,0.00001626733,0.0004611966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00178075,"threshold_uncertainty_score":0.005957186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02395111800139674,"score_gpt":0.2710448891130719,"score_spread":0.2470937711116752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}