{"id":"W2057231053","doi":"10.1080/15287394.2011.618973","title":"Upregulation of Micro RNA-146a (miRNA-146a), A Marker for Inflammatory Neurodegeneration, in Sporadic Creutzfeldt–Jakob Disease (sCJD) and Gerstmann–Straussler–Scheinker (GSS) Syndrome","year":2011,"lang":"en","type":"article","venue":"Journal of Toxicology and Environmental Health","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Norgen Biotek Corporation (Canada)","funders":"National Institute on Aging","keywords":"Neurodegeneration; Downregulation and upregulation; Innate immune system; Immune system; Microglia; Biology; Human brain; Inflammation; Neuroinflammation; Neuropathology; Immunology; microRNA; Disease; Virology; Neuroscience; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003409444,0.0001357186,0.0002293138,0.0001013955,0.00007622041,0.000006211527,0.00007031902,0.0001273677,0.00004231133],"category_scores_gemma":[0.00002191085,0.0001296951,0.00007484073,0.00002913486,0.000179557,0.00002679429,0.00003999264,0.00008922086,5.058506e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003598925,"about_ca_system_score_gemma":0.0001032314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004678362,"about_ca_topic_score_gemma":0.00001373811,"domain_scores_codex":[0.9988835,0.0001166257,0.0005209564,0.0002002107,0.00009577434,0.0001828626],"domain_scores_gemma":[0.9991778,0.00001514107,0.000387274,0.0001301369,0.00001364378,0.0002760298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004101253,0.0008427168,0.7494828,0.0003216452,0.0001134169,0.00006773756,0.0004914982,0.0003477971,0.2373913,0.0002367844,0.0008460596,0.005757044],"study_design_scores_gemma":[0.001674218,0.000801103,0.9917223,0.00002828518,0.00003124268,0.0001280357,0.0001020922,0.0002130364,0.004055341,0.0002138847,0.0009114193,0.0001189711],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964249,0.00255362,0.0002605619,0.0003682257,0.0001090561,0.0002220836,0.00003571566,0.000001872523,0.0000239316],"genre_scores_gemma":[0.9974533,0.0009662342,0.000799078,0.0005119271,0.00005911207,0.000008419382,0.00004678599,0.00001488116,0.0001403158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2422396,"threshold_uncertainty_score":0.5288813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01217014294610777,"score_gpt":0.2320965721850358,"score_spread":0.2199264292389281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}