{"id":"W2057231053","doi":"10.1080/15287394.2011.618973","title":"Upregulation of Micro RNA-146a (miRNA-146a), A Marker for Inflammatory Neurodegeneration, in Sporadic Creutzfeldt–Jakob Disease (sCJD) and Gerstmann–Straussler–Scheinker (GSS) Syndrome","year":2011,"lang":"en","type":"article","venue":"Journal of Toxicology and Environmental Health","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Norgen Biotek Corporation (Canada)","funders":"National Institute on Aging","keywords":"Neurodegeneration; Downregulation and upregulation; Innate immune system; Immune system; Microglia; Biology; Human brain; Inflammation; Neuroinflammation; Neuropathology; Immunology; microRNA; Disease; Virology; Neuroscience; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001263203,0.0002263698,0.0002351147,0.0009352557,0.0001441642,0.0002372205,0.00007521585,0.0003115212,0.0007232753],"category_scores_gemma":[0.0002666309,0.0001853869,0.000211142,0.0003639044,0.0002475275,0.000132735,0.0001757377,0.0002253538,0.0001994481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009880332,"about_ca_system_score_gemma":0.00006848678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000266078,"about_ca_topic_score_gemma":0.0003755329,"domain_scores_codex":[0.999851,0.00001877045,0.00002934237,0.00005126666,0.00003374601,0.00001595276],"domain_scores_gemma":[0.9997908,0.00002628871,0.0001063815,0.00001281371,0.00001931796,0.00004436637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006263781,0.00003575485,0.01950277,0.00009934641,0.00004238957,0.0006961499,0.0001009039,0.00004393243,0.9763593,0.00004041479,0.00004690264,0.002405711],"study_design_scores_gemma":[0.00003877941,0.0008801076,0.7012022,0.00001777972,0.0001459944,0.01254911,0.000178857,0.0008203932,0.282289,0.0001786161,0.001680123,0.00001903753],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976351,0.001219153,0.0004449816,0.00001045901,0.000009607799,0.00001158683,0.0003128911,0.00002011627,0.0003359549],"genre_scores_gemma":[0.998019,0.0004047241,0.0007699154,0.00001875021,0.000005878685,0.00001775265,0.000351682,0.000004333856,0.0004080795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009352557,"threshold_uncertainty_score":0.002419591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01217014294610777,"score_gpt":0.2320965721850358,"score_spread":0.2199264292389281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}