{"id":"W2057271915","doi":"10.1186/1471-2105-10-s8-s8","title":"Correlating protein function and stability through the analysis of single amino acid substitutions","year":2009,"lang":"en","type":"article","venue":"BMC Bioinformatics","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"U.S. National Library of Medicine; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Mutation; Function (biology); Stability (learning theory); Genetics; Protein structure; Computational biology; Biology; Amino acid; Protein stability; Gene; Biochemistry; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001287776,0.00009324914,0.0001279823,0.00003156996,0.0001126417,0.0000210803,0.00008530046,0.0001000674,0.000004802465],"category_scores_gemma":[0.0001107908,0.00006535538,0.00008199175,0.0002587998,0.000120543,0.00001423671,0.00003880872,0.00006231599,6.38995e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009727674,"about_ca_system_score_gemma":0.00003634437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009127721,"about_ca_topic_score_gemma":0.00007103261,"domain_scores_codex":[0.9993869,0.00002360077,0.0002816699,0.00009348076,0.00009928365,0.0001150526],"domain_scores_gemma":[0.9994284,0.00001083378,0.0001638673,0.0003054616,0.00006789147,0.00002354004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003584018,0.0002704285,0.02880833,0.0002851912,0.0009004541,3.543945e-7,0.002563179,0.007493585,0.9006962,0.02783901,0.0001238754,0.03066104],"study_design_scores_gemma":[0.002173624,0.002412223,0.2686041,0.00008918908,0.002967419,0.00002755225,0.004772492,0.3761437,0.3212377,0.01701822,0.003360692,0.001193092],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.585692,0.0002270592,0.4126194,0.00002989664,0.00002751356,0.0002208705,0.00002572982,0.000008871451,0.001148624],"genre_scores_gemma":[0.9686645,0.000008757215,0.03106846,0.00009762241,0.00002182039,0.000005117266,0.0001160105,0.000002513115,0.00001522108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5794584,"threshold_uncertainty_score":0.2665115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01572823768059156,"score_gpt":0.2325805705035063,"score_spread":0.2168523328229147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}