{"id":"W2057287073","doi":"10.4161/cbt.18921","title":"Selective tumor killing based on specific DNA-damage response deficiencies","year":2012,"lang":"en","type":"review","venue":"Cancer Biology & Therapy","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatoon Medical Imaging; University of Saskatchewan","funders":"","keywords":"DNA damage; Genome instability; Carcinogenesis; Biology; Cancer research; DNA repair; DNA; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003169695,0.000858775,0.001240165,0.001598946,0.0001908053,0.0005954803,0.0008900795,0.0007258561,0.001710388],"category_scores_gemma":[0.0002786105,0.0002227001,0.000369147,0.001079447,0.0004336121,0.0007202908,0.0004217789,0.001274258,0.001725462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005504135,"about_ca_system_score_gemma":0.0003307709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000593004,"about_ca_topic_score_gemma":0.001076778,"domain_scores_codex":[0.9998782,0.0000157836,0.00001147783,0.00002724754,0.00005192248,0.00001542402],"domain_scores_gemma":[0.9999088,0.00003421677,0.00001786593,0.000004610185,0.0000242043,0.00001029155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008269594,0.0001368674,0.0001960407,0.008678756,0.00006296716,0.0003597925,0.00005302655,0.0007081019,0.01626701,0.004900367,0.01681152,0.9517429],"study_design_scores_gemma":[0.0000333125,0.0001908048,0.0009524301,0.001130414,0.00007550108,0.002993294,0.0000378041,0.0001800922,0.01114144,0.002064328,0.9811738,0.00002673155],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007122503,0.9958846,0.0006921954,0.0001599963,0.0001451897,0.00001338865,0.0000262369,0.0000250148,0.002341083],"genre_scores_gemma":[0.003103103,0.9943151,0.0005294953,0.0001555314,0.00005854051,0.00001833141,0.00005528114,0.000004246338,0.001760324],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001710388,"threshold_uncertainty_score":0.005721807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05564201934360715,"score_gpt":0.3354255949538186,"score_spread":0.2797835756102114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}