{"id":"W2057290386","doi":"10.1515/bc.2003.066","title":"Modulation of the Chymotrypsin-Like Activity of the 20S Proteasome by Intracellular Redox Status: Effects of Glutathione Peroxidase-1 Overexpression and Antioxidant Drugs","year":2003,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Selenium in Biological Systems","field":"Nursing","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Université Laval; Association pour la Recherche sur le Cancer","keywords":"Proteasome; Intracellular; Glutathione peroxidase; Glutathione; Biochemistry; HeLa; Proteolysis; Antioxidant; Chymotrypsin; Chemistry; Reactive oxygen species; Enzyme; Molecular biology; In vitro; Biology; Trypsin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003353262,0.0002087075,0.0003937478,0.000008158984,0.0000941864,0.000007498797,0.0002478405,0.0004250143,0.00002752022],"category_scores_gemma":[0.00105023,0.0001013313,0.000145113,0.0001941011,0.0005305771,0.00004145987,0.0001253736,0.0002794881,3.786282e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005931947,"about_ca_system_score_gemma":0.00001775404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003344789,"about_ca_topic_score_gemma":1.103325e-7,"domain_scores_codex":[0.9981856,0.0005053888,0.0004029403,0.0003562527,0.0002838538,0.00026595],"domain_scores_gemma":[0.9984754,0.0003666339,0.000579202,0.0004349051,0.00007579973,0.00006809997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001627758,0.0002604118,0.01812175,0.0004342406,0.00001454101,1.3287e-7,0.00007668849,0.000005411007,0.9804992,0.00001730804,0.00007847698,0.0003290409],"study_design_scores_gemma":[0.0004852854,0.0001032419,0.08201613,0.0003175136,0.00001476402,0.000004099259,0.00004899621,0.0000707648,0.9162858,0.0002408865,0.0002935358,0.0001190072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979157,0.0008739314,0.00003311724,0.00007665778,0.0001895995,0.0006769179,0.00004161984,0.00002261398,0.000169833],"genre_scores_gemma":[0.9997301,0.00002621279,0.0001018631,0.00001947409,0.00003144794,0.00002146801,0.000005744686,0.000009390649,0.0000542836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06421345,"threshold_uncertainty_score":0.4132172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00800371285196046,"score_gpt":0.2160122988902174,"score_spread":0.208008586038257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}