{"id":"W2057290386","doi":"10.1515/bc.2003.066","title":"Modulation of the Chymotrypsin-Like Activity of the 20S Proteasome by Intracellular Redox Status: Effects of Glutathione Peroxidase-1 Overexpression and Antioxidant Drugs","year":2003,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Selenium in Biological Systems","field":"Nursing","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Université Laval; Association pour la Recherche sur le Cancer","keywords":"Proteasome; Intracellular; Glutathione peroxidase; Glutathione; Biochemistry; HeLa; Proteolysis; Antioxidant; Chymotrypsin; Chemistry; Reactive oxygen species; Enzyme; Molecular biology; In vitro; Biology; Trypsin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003486692,0.0005995667,0.0006993062,0.000212376,0.0001690032,0.000468861,0.0002432853,0.0003454013,0.0008487902],"category_scores_gemma":[0.0001694689,0.000201374,0.0004107041,0.0002691628,0.0003150874,0.000345926,0.0001854178,0.0007103738,0.0001896883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002761089,"about_ca_system_score_gemma":0.0002041332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005159759,"about_ca_topic_score_gemma":0.0006222889,"domain_scores_codex":[0.9997525,0.0000569457,0.00003843626,0.00004904103,0.00002996415,0.0000731465],"domain_scores_gemma":[0.9998214,0.00003756319,0.00003754253,0.00002375277,0.00002335762,0.00005640796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007804324,0.0001647326,0.0001140429,0.00005162694,0.00001177064,0.00004399879,0.00002214576,0.00003623814,0.9978535,0.0000320521,0.00002534425,0.0008641455],"study_design_scores_gemma":[0.00005613829,0.001159154,0.00219113,0.000004194333,0.00003802566,0.00006797147,0.00002729166,0.0004413051,0.9952551,0.00002064515,0.0007334331,0.000005587238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959584,0.002620333,0.0005950539,0.0001159091,0.00005345627,0.00002562469,0.000178797,0.00003772538,0.0004147567],"genre_scores_gemma":[0.9942873,0.001883744,0.00146446,0.00005750181,0.00003370394,0.00006489774,0.0004807331,0.00002147116,0.001706198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008487902,"threshold_uncertainty_score":0.002839506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00800371285196046,"score_gpt":0.2160122988902174,"score_spread":0.208008586038257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}