{"id":"W2057295709","doi":"10.1074/jbc.m112.420414","title":"Characterization of a Flavoprotein Oxidase from Opium Poppy Catalyzing the Final Steps in Sanguinarine and Papaverine Biosynthesis","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; University of Calgary","funders":"","keywords":"Sanguinarine; Papaverine; Opium Poppy; Flavoprotein; Biosynthesis; Chemistry; Biochemistry; Papaver; Stereochemistry; Biology; Enzyme; Alkaloid; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001363357,0.0003422592,0.0002448547,0.0002399681,0.0001424763,0.0003044612,0.0001668127,0.000222308,0.0003120533],"category_scores_gemma":[0.0002481279,0.00008807595,0.0003081165,0.0003082466,0.0001475796,0.0002105453,0.0002374505,0.0004318101,0.0002276594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002127633,"about_ca_system_score_gemma":0.0002500036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001624126,"about_ca_topic_score_gemma":0.0008340426,"domain_scores_codex":[0.9999343,0.000007676956,0.00000653308,0.0000164586,0.00002160485,0.00001337921],"domain_scores_gemma":[0.9998456,0.00003436844,0.00003613876,0.00001547497,0.00002938332,0.00003890921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002748949,0.00001488284,0.000261591,0.00002214008,0.000003165933,0.00007636283,0.00001660098,0.00002821111,0.9986919,0.00002814343,0.00001091751,0.0008186105],"study_design_scores_gemma":[0.00002055008,0.0002465479,0.04290026,0.00001464773,0.00006670841,0.001348527,0.0001830871,0.001956537,0.9469062,0.0001457628,0.006196905,0.00001427524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914004,0.0007139592,0.005903251,0.0002327495,0.00001918309,0.0000485072,0.001012256,0.00004938959,0.0006203976],"genre_scores_gemma":[0.9787472,0.001204226,0.00983385,0.0001436829,0.00002097182,0.00004349821,0.007065502,0.00004358724,0.00289744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001624126,"threshold_uncertainty_score":0.00322932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04686884061708278,"score_gpt":0.2877139453818609,"score_spread":0.2408451047647781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}