{"id":"W2057317175","doi":"10.1159/000345240","title":"Insights into the Activity, Differential Expression, Mutual Regulation, and Functions of Matrix Metalloproteinases and A Disintegrin and Metalloproteinases in Hypertension and Cardiac Disease","year":2012,"lang":"en","type":"review","venue":"Journal of Vascular Research","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Matrix metalloproteinase; Disintegrin; Downregulation and upregulation; Receptor; Biology; Medicine; Endocrinology; Bioinformatics; Internal medicine; Metalloproteinase; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001088714,0.0002637746,0.0008467948,0.0003278667,0.0001973602,0.00007256809,0.0001446134,0.0002319955,0.000005568846],"category_scores_gemma":[0.0004361994,0.0001517059,0.0002621993,0.0001725882,0.0003347549,0.00004151917,0.0005596468,0.0005055537,3.042389e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002048564,"about_ca_system_score_gemma":0.000180489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006703084,"about_ca_topic_score_gemma":0.00001408107,"domain_scores_codex":[0.9973323,0.001116317,0.0004571993,0.0003352319,0.0005375018,0.0002214237],"domain_scores_gemma":[0.9987323,0.0001234668,0.0002775964,0.0003414067,0.0002738815,0.0002513013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005799263,0.0004475405,0.0001730745,0.007500919,0.001137771,0.00004646188,0.0002131076,6.505234e-7,0.5314617,0.0003433852,0.0001356294,0.4579598],"study_design_scores_gemma":[0.004608216,0.003448089,0.008472987,0.02276104,0.006619341,0.0005230553,0.0009082388,0.00007532003,0.1377742,0.003037232,0.8100018,0.001770479],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3502109,0.6490766,0.0000888361,0.00002577018,0.0000418437,0.0005457689,0.000007274298,0.000001048117,0.000001905449],"genre_scores_gemma":[0.3258729,0.6736875,0.00009456708,0.00000115449,0.0002004926,0.00004823435,0.00001376375,0.00002140591,0.00006002888],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8098662,"threshold_uncertainty_score":0.6186388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05171030456540522,"score_gpt":0.3376447618758958,"score_spread":0.2859344573104906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}