{"id":"W2057317668","doi":"10.1371/journal.pone.0082106","title":"SIRT1 Catalytic Activity Has Little Effect on Tumor Formation and Metastases in a Mouse Model of Breast Cancer","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research; University of Ottawa","keywords":"Carcinogenesis; Cancer research; Mammary tumor; Oncogene; Transgene; Mouse mammary tumor virus; Genetically modified mouse; Suppressor; Mutant; Biology; Cancer; Breast cancer; Mammary gland; Tumor progression; Sirtuin 1; Tumor initiation; Internal medicine; Immunology; Medicine; Downregulation and upregulation; Cell cycle; Genetics; Gene; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005349691,0.001016351,0.0009008599,0.001320342,0.0003783024,0.0005254556,0.0006787581,0.001072101,0.003502229],"category_scores_gemma":[0.000332326,0.0005867942,0.0006907284,0.0004873475,0.0009724952,0.0005620937,0.0003456626,0.002773875,0.0007968734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007899702,"about_ca_system_score_gemma":0.0007153763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002028333,"about_ca_topic_score_gemma":0.004189493,"domain_scores_codex":[0.9992938,0.0001213306,0.00005368396,0.0001739632,0.0002085161,0.0001486667],"domain_scores_gemma":[0.9992306,0.0001180243,0.0001705389,0.0001109647,0.00005072263,0.0003190857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008956344,0.0003378175,0.0002988083,0.00004206462,0.0000182854,0.00010272,0.00003360843,0.0001034953,0.9961869,0.0002898058,0.0001498188,0.001540995],"study_design_scores_gemma":[0.0001311659,0.003396652,0.003187219,0.00001857697,0.00006145958,0.000529216,0.00005751116,0.001380251,0.9865673,0.0002868199,0.004361249,0.00002264016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863283,0.002757319,0.004145924,0.001044782,0.0002739983,0.00007891701,0.001339815,0.0004726584,0.003558247],"genre_scores_gemma":[0.976729,0.002223457,0.00347243,0.0003340882,0.0000549268,0.000145711,0.001701736,0.0002396625,0.015099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003502229,"threshold_uncertainty_score":0.01171607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04374466375734975,"score_gpt":0.2574562077063317,"score_spread":0.213711543948982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}