{"id":"W2057320973","doi":"10.1021/ja104488d","title":"Chemoselective Peptidomimetic Ligation Using Thioacid Peptides and Aziridine Templates","year":2010,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Peptidomimetic; Chemoselectivity; Cysteine; Amino acid; Peptide bond; Peptide; Tripeptide; Native chemical ligation; Thiazolidine; Nucleophile; Combinatorial chemistry; Electrophile; Aziridine; Glutathione; Alanine; Amide; Chemical ligation; Stereochemistry; Biochemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002268599,0.0001221531,0.0002520339,0.000009373978,0.00008410146,0.00002733543,0.0002110661,0.00007593576,0.000006908483],"category_scores_gemma":[0.0002918263,0.00007859079,0.0004202835,0.0001734034,0.0004136443,0.000006493234,0.000117484,0.000304964,3.37626e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002307791,"about_ca_system_score_gemma":0.00004427216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001937558,"about_ca_topic_score_gemma":0.000001454376,"domain_scores_codex":[0.9992573,0.00002378422,0.0002460491,0.0001542426,0.0001662798,0.0001522947],"domain_scores_gemma":[0.9991221,0.0000498605,0.0004559308,0.0001549169,0.0001313433,0.00008585111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002954806,0.00003380072,0.004985551,0.000004821317,0.0001343311,1.496318e-7,0.00004125884,0.000004299739,0.9928985,0.000001870711,0.0006392412,0.00122665],"study_design_scores_gemma":[0.0001844115,0.00003936326,0.001345784,0.00001343452,0.0001069307,0.00007493769,0.000136351,0.0002493854,0.9968516,0.0001219538,0.000768475,0.0001073265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989772,0.0001079005,0.0001166521,0.0006862913,0.00003662418,0.0000341089,0.000002421168,0.000002625008,0.00003610867],"genre_scores_gemma":[0.9933534,0.0001015368,0.005615072,0.0003591336,0.0005338753,7.974985e-7,0.000001459417,0.00001281242,0.00002194795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005623903,"threshold_uncertainty_score":0.3204839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006189903333278594,"score_gpt":0.2443789020028129,"score_spread":0.2381889986695343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}