{"id":"W2057337596","doi":"10.1016/j.bpj.2011.11.1677","title":"Probing the Structural and Signalling Roles of Ceramide using 6-Bromo-7-Hydroxycoumarin Caged Derivatives","year":2012,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences; Steacie Institute for Molecular Sciences","funders":"","keywords":"Ceramide; Sphingomyelin; Lipid signaling; Sphingomyelin phosphodiesterase; Chemistry; Sphingolipid; Membrane; Biochemistry; Biophysics; Sphingosine; Cell biology; Enzyme; Apoptosis; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839506,0.0002392033,0.0001658309,0.0001086596,0.000194115,0.0002455715,0.0003801579,0.0004301362,0.001130837],"category_scores_gemma":[0.0001906431,0.0001313666,0.000166343,0.0001225147,0.0003591993,0.0003113277,0.000172978,0.0007091782,0.0002620564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004797973,"about_ca_system_score_gemma":0.0001768443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000659956,"about_ca_topic_score_gemma":0.0005920291,"domain_scores_codex":[0.999897,0.0000202212,0.000005879847,0.00002094811,0.00002913373,0.00002687062],"domain_scores_gemma":[0.9998565,0.0000428117,0.00003656096,0.00001773931,0.00001578717,0.00003068889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001463341,0.00001038913,0.00005438712,0.00001105233,0.000002921689,0.00003950544,0.00001180226,0.00009526956,0.9991921,0.0001085097,0.00001334293,0.000314224],"study_design_scores_gemma":[0.00001289281,0.00005768727,0.0004401431,0.000001151882,0.000004221036,0.00004987563,0.0000124529,0.0005790425,0.9983889,0.00003042841,0.0004201726,0.000003214504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972222,0.000379154,0.001336857,0.000124711,0.00001477074,0.000007457036,0.0001065893,0.00001966902,0.0007886073],"genre_scores_gemma":[0.9973038,0.0003899868,0.001187265,0.00004338277,0.000005197495,0.00001081683,0.000163634,0.00001059767,0.0008852367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001130837,"threshold_uncertainty_score":0.003783047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01644914680613099,"score_gpt":0.2638621343527323,"score_spread":0.2474129875466013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}