{"id":"W2057358289","doi":"10.1002/bip.10383","title":"Transmembrane segment peptides with double <scp>D</scp>‐amino acid replacements: Helicity, hydrophobicity, and antimicrobial activity","year":2003,"lang":"en","type":"article","venue":"Biopolymers","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Chemistry; Peptide; Circular dichroism; Antimicrobial peptides; Transmembrane domain; Transmembrane protein; Peptide sequence; Micelle; Escherichia coli; Membrane; Amino acid; Biophysics; Stereochemistry; Biochemistry; Aqueous solution; Receptor; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002279271,0.0004858203,0.000543773,0.000163634,0.0005199022,0.0000858458,0.0002023119,0.0003062954,0.0002023683],"category_scores_gemma":[0.00001915131,0.0004125401,0.0001346619,0.0002106595,0.0008473896,0.0003281363,0.00008840988,0.0003663792,0.0001107789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006554179,"about_ca_system_score_gemma":0.0001048327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007264803,"about_ca_topic_score_gemma":0.0001121351,"domain_scores_codex":[0.9979458,0.0001613197,0.0002978081,0.0007092201,0.00008516377,0.000800626],"domain_scores_gemma":[0.9991971,0.0001059912,0.0001951442,0.0003728124,0.00004564584,0.00008329633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003196087,0.0003196348,0.001484405,0.00008408876,0.0003286607,0.0000141553,0.000592938,0.000006962732,0.992786,0.000294829,0.003179087,0.0005895671],"study_design_scores_gemma":[0.003976469,0.0004410027,0.0004595398,0.0000839506,0.0001227166,0.0002974937,0.0007901965,0.000001358193,0.982843,0.000009748634,0.01071381,0.0002607564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904549,0.0010389,0.0003148143,0.000167133,0.000423867,0.0004687278,0.00008463058,0.000137387,0.006909656],"genre_scores_gemma":[0.9897677,0.0003641943,0.0002188103,0.0004067462,0.00003491139,0.00002060577,0.00005140331,0.00005217672,0.009083488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009943105,"threshold_uncertainty_score":0.9998326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130712186183733,"score_gpt":0.2172366917658847,"score_spread":0.2059295699040473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}