{"id":"W2057358289","doi":"10.1002/bip.10383","title":"Transmembrane segment peptides with double <scp>D</scp>‐amino acid replacements: Helicity, hydrophobicity, and antimicrobial activity","year":2003,"lang":"en","type":"article","venue":"Biopolymers","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Chemistry; Peptide; Circular dichroism; Antimicrobial peptides; Transmembrane domain; Transmembrane protein; Peptide sequence; Micelle; Escherichia coli; Membrane; Amino acid; Biophysics; Stereochemistry; Biochemistry; Aqueous solution; Receptor; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001874936,0.0003167094,0.0002728395,0.0001223136,0.0001093241,0.0002196282,0.0001480482,0.0002379962,0.0005573393],"category_scores_gemma":[0.000264672,0.0000975415,0.000217442,0.0002509005,0.0001989683,0.0001389206,0.0001593904,0.0003673193,0.000159092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001807209,"about_ca_system_score_gemma":0.0001580542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003505503,"about_ca_topic_score_gemma":0.0005418641,"domain_scores_codex":[0.9998429,0.00003845308,0.00002724688,0.00002783183,0.00003620551,0.00002731469],"domain_scores_gemma":[0.9997532,0.00005673541,0.00007868328,0.00002482433,0.00003167012,0.00005487198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001211742,0.0000191939,0.0005077367,0.00001898905,0.000008457553,0.00008689441,0.000007977139,0.0001231992,0.9979602,0.00002094341,0.00001111022,0.001114102],"study_design_scores_gemma":[0.00001805004,0.000537522,0.006936221,0.000005372939,0.00003423245,0.0008751472,0.00001979998,0.0008088885,0.9899843,0.00002026361,0.0007534236,0.000006819428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977965,0.0004958402,0.001162301,0.00003535449,0.000008594486,0.00002436062,0.000124928,0.00001652474,0.0003355154],"genre_scores_gemma":[0.99721,0.0002026582,0.002060614,0.00004108868,0.000005188276,0.00001638452,0.0002285803,0.000009837602,0.0002256483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005573393,"threshold_uncertainty_score":0.001864493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130712186183733,"score_gpt":0.2172366917658847,"score_spread":0.2059295699040473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}