{"id":"W2057358596","doi":"10.1016/j.cell.2010.08.023","title":"Phosphotyrosine Signaling: Evolving a New Cellular Communication System","year":2010,"lang":"en","type":"article","venue":"Cell","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":347,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Eye Institute; Howard Hughes Medical Institute","keywords":"Biology; SH2 domain; Proto-oncogene tyrosine-protein kinase Src; Phosphorylation; Protein tyrosine phosphatase; Signal transduction; Cell biology; Tyrosine phosphorylation; Tyrosine; Kinase; Receptor tyrosine kinase; Cell signaling; Homology (biology); Tyrosine kinase; Computational biology; Genetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724026,0.0001456149,0.0001152919,0.00002209872,0.0001181287,0.00005126595,0.0004001889,0.0001476615,0.00008375584],"category_scores_gemma":[0.00006266724,0.0001496104,0.0000670739,0.00007604108,0.000052054,0.000005420115,0.0001732362,0.0001680755,0.00007822352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001279666,"about_ca_system_score_gemma":0.00009973521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001666437,"about_ca_topic_score_gemma":0.00002027483,"domain_scores_codex":[0.999205,0.00003233845,0.0001851965,0.0002651312,0.0001060327,0.0002063143],"domain_scores_gemma":[0.9988313,0.00001119855,0.0001066577,0.0008492893,0.00007640289,0.0001251446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000172352,0.00002860658,0.0001408463,0.00003296807,0.000007327038,0.000002000661,0.00002274413,0.000008650183,0.9901854,0.0006576013,0.00860993,0.0002867053],"study_design_scores_gemma":[0.0003898909,0.0000532681,0.0000802364,0.00002145886,0.00001650567,0.000006027264,0.00003818233,0.0001246647,0.9492137,0.00004577798,0.04984213,0.0001681036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.910594,0.06907017,0.01018546,0.0002266239,0.0008269231,0.0006846396,0.00004538301,0.0001596565,0.008207122],"genre_scores_gemma":[0.9882645,0.0000412976,0.00920298,0.0000891552,0.0002330035,0.00001743689,0.0003010445,0.00003254189,0.001818064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07767045,"threshold_uncertainty_score":0.6100934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006542311322408689,"score_gpt":0.2099112807256839,"score_spread":0.2033689694032752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}