{"id":"W2057416509","doi":"10.2174/13816128113199990313","title":"Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Inhibitors in the Treatment of Hypercholesterolemia and other Pathologies","year":2013,"lang":"en","type":"review","venue":"Current Pharmaceutical Design","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Core Research for Evolutional Science and Technology; Canadian Institutes of Health Research; Pfizer","keywords":"PCSK9; Kexin; Proprotein convertase; Subtilisin; Familial hypercholesterolemia; Medicine; LDL receptor; Proprotein Convertases; Pharmacology; Cholesterol; Chemistry; Endocrinology; Biochemistry; Lipoprotein; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000470065,0.000320382,0.0006394415,0.0009368705,0.0001547281,0.000576356,0.0003161809,0.0005877839,0.002090951],"category_scores_gemma":[0.0004792735,0.0001120652,0.0004013949,0.0006266999,0.0002333402,0.0003473635,0.0003543543,0.001393143,0.0008905085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003111057,"about_ca_system_score_gemma":0.0004644775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005039827,"about_ca_topic_score_gemma":0.001470831,"domain_scores_codex":[0.9997693,0.00004915836,0.00003773094,0.00002899682,0.00008901361,0.00002580542],"domain_scores_gemma":[0.9997919,0.00006505061,0.00004855571,0.000005857236,0.0000593613,0.00002926859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008584327,0.0001928932,0.0006934137,0.006407362,0.0002214664,0.0009260094,0.00009366162,0.0004574668,0.01776039,0.004668017,0.03378841,0.9339325],"study_design_scores_gemma":[0.0003420727,0.001572542,0.006095125,0.002590131,0.0004383391,0.005435239,0.0001074705,0.0005962924,0.009783629,0.004421813,0.9685583,0.00005904224],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002367432,0.9928519,0.0005445561,0.001299418,0.0005705039,0.00001116475,0.00005019144,0.00002615612,0.002278653],"genre_scores_gemma":[0.02067216,0.9728579,0.001052076,0.0009690964,0.001163299,0.00002130199,0.0001409814,0.000008789644,0.003114384],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002090951,"threshold_uncertainty_score":0.006994963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2804797153982914,"score_gpt":0.4420727696308272,"score_spread":0.1615930542325358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}