{"id":"W2057544544","doi":"10.1016/j.bmc.2009.01.055","title":"Synthesis of (−)-lobeline via enzymatic desymmetrization of lobelanidine","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"PROTEO; Université Laval","funders":"","keywords":"Chemistry; Desymmetrization; Enzyme; Stereochemistry; Biochemistry; Enantioselective synthesis; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002029711,0.0004660975,0.0002192515,0.0002485794,0.0002072818,0.0002171033,0.0004961428,0.000322159,0.002635424],"category_scores_gemma":[0.0001866136,0.000124613,0.0003434069,0.000252042,0.0002053974,0.0003849712,0.0003498985,0.0004503049,0.001238703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004501138,"about_ca_system_score_gemma":0.0006903513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001199551,"about_ca_topic_score_gemma":0.002017267,"domain_scores_codex":[0.9998764,0.00001563898,0.00001305072,0.00002561374,0.00001829474,0.00005108933],"domain_scores_gemma":[0.9999222,0.000008185315,0.00001741813,0.00001580053,0.00001474691,0.00002169659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002565178,0.0001061257,0.0003002199,0.0003293548,0.0000365652,0.0009090046,0.0002870078,0.001003459,0.9698528,0.002775384,0.001200616,0.0229429],"study_design_scores_gemma":[0.00004758466,0.001040601,0.001426967,0.00001784605,0.00002353952,0.0006383301,0.00005405677,0.0005915672,0.9726298,0.0004678619,0.02302967,0.0000321622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9147569,0.00406721,0.03753517,0.0006146085,0.0003724431,0.0003038428,0.00264656,0.0006689967,0.03903429],"genre_scores_gemma":[0.9835401,0.001533236,0.007871531,0.0001294919,0.00003267836,0.00005649212,0.00103426,0.00005910935,0.005743276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002635424,"threshold_uncertainty_score":0.008816361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007401174701064645,"score_gpt":0.216115896997088,"score_spread":0.2087147222960233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}