{"id":"W2057582738","doi":"10.1210/en.2013-1363","title":"Loss of Vascular Endothelial Growth Factor A (VEGFA) Isoforms in the Testes of Male Mice Causes Subfertility, Reduces Sperm Numbers, and Alters Expression of Genes That Regulate Undifferentiated Spermatogonia","year":2013,"lang":"en","type":"article","venue":"Endocrinology","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institutes of Health","keywords":"Endocrinology; Internal medicine; Gene isoform; Sperm; Vascular endothelial growth factor A; Biology; Vascular endothelial growth factor; Gene; Andrology; Gene expression; VEGF receptors; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006197814,0.0001761343,0.0004677381,0.0001633156,0.00002854636,0.000006541969,0.000134259,0.00008887224,0.0002596714],"category_scores_gemma":[0.0001473743,0.0001102652,0.0001003185,0.0001344253,0.000374212,0.0001111681,0.00007490575,0.0001273268,0.000004256677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001710828,"about_ca_system_score_gemma":0.00003183078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001548773,"about_ca_topic_score_gemma":0.00006099927,"domain_scores_codex":[0.9987538,0.000120669,0.000386324,0.0002401758,0.0002219765,0.0002770947],"domain_scores_gemma":[0.9991235,0.0002300306,0.0001978786,0.000294232,0.000107508,0.00004685697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008774497,0.0001432878,0.5258195,0.0001828496,0.00005224513,0.00001481582,0.0006622819,6.69364e-7,0.4727038,0.00007045079,0.00002046266,0.000241928],"study_design_scores_gemma":[0.0009232556,0.0001383518,0.5060632,0.00009019439,0.00005636381,0.0001985985,0.0004395371,0.00001503046,0.4918518,0.0001573108,0.00001179565,0.00005460335],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998024,0.001015116,0.0000138285,0.0001866638,0.0001192128,0.0004772001,0.00002283969,0.00001754533,0.0001235289],"genre_scores_gemma":[0.9991322,0.0005605113,0.0001462409,0.00003103645,0.00003088432,0.00001917467,0.00002134502,0.00001513178,0.00004350269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01975635,"threshold_uncertainty_score":0.4496484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01978894578209787,"score_gpt":0.2467992719486863,"score_spread":0.2270103261665884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}