{"id":"W2057587429","doi":"10.1038/gt.2012.68","title":"Synergistic cytotoxicity of oncolytic reovirus in combination with cisplatin–paclitaxel doublet chemotherapy","year":2012,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"National Cancer Institute; Oncolytics Biotech; Cancer Research UK","keywords":"Oncolytic virus; Paclitaxel; Cisplatin; Taxane; Chemotherapy; Cancer research; Head and neck cancer; Combination therapy; Cytotoxicity; Combination chemotherapy; Oncology; Medicine; Cancer; Virology; Pharmacology; Internal medicine; Biology; In vitro; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007528726,0.0002479406,0.0002979198,0.0001439809,0.00005858509,0.00001484213,0.0002959379,0.0001725215,0.0001046896],"category_scores_gemma":[0.00002358113,0.0002135549,0.00008129693,0.0003333577,0.0001565175,0.0000132298,0.00003675234,0.0001492695,0.0000130283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006853016,"about_ca_system_score_gemma":0.0001546394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007092685,"about_ca_topic_score_gemma":0.0001197069,"domain_scores_codex":[0.9982741,0.0001924157,0.0003301742,0.0003270975,0.0003502625,0.0005259812],"domain_scores_gemma":[0.9989587,0.00003595683,0.0001566273,0.0006003002,0.0001196997,0.0001287037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00765061,0.0006072587,0.01007767,0.00001573109,0.00009574777,0.000001996037,0.000226735,0.0001392766,0.9739179,0.00007219244,0.000113471,0.007081387],"study_design_scores_gemma":[0.005175583,0.004558946,0.01269038,0.00001754647,0.00000578522,0.00000654984,0.00003662189,0.00005657984,0.9761866,0.00009316293,0.000906944,0.0002652964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961351,0.001813798,0.0006796824,0.0001310009,0.00006460949,0.0005887306,0.00001758369,0.00001628986,0.0005532321],"genre_scores_gemma":[0.9972382,0.001073035,0.0006160502,0.0003774338,0.0001780233,0.00008415235,0.00007435231,0.00006086484,0.000297956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006816091,"threshold_uncertainty_score":0.8708515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02397662582149871,"score_gpt":0.3020503082894053,"score_spread":0.2780736824679066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}