{"id":"W2057587429","doi":"10.1038/gt.2012.68","title":"Synergistic cytotoxicity of oncolytic reovirus in combination with cisplatin–paclitaxel doublet chemotherapy","year":2012,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"National Cancer Institute; Oncolytics Biotech; Cancer Research UK","keywords":"Oncolytic virus; Paclitaxel; Cisplatin; Taxane; Chemotherapy; Cancer research; Head and neck cancer; Combination therapy; Cytotoxicity; Combination chemotherapy; Oncology; Medicine; Cancer; Virology; Pharmacology; Internal medicine; Biology; In vitro; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003389327,0.000553602,0.001083276,0.0007659277,0.0003604761,0.0006098325,0.0005766007,0.0004863573,0.001842213],"category_scores_gemma":[0.0004104851,0.0002871671,0.0005532037,0.0006232261,0.0003787765,0.0004190523,0.000373134,0.0009267415,0.0003971665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006636265,"about_ca_system_score_gemma":0.000908096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00175721,"about_ca_topic_score_gemma":0.002933092,"domain_scores_codex":[0.9996673,0.0001141808,0.0000247493,0.00004450861,0.00006114795,0.00008813194],"domain_scores_gemma":[0.9998197,0.00005970155,0.00002016172,0.00003823221,0.00001593076,0.00004626009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01881179,0.003477877,0.001892655,0.0005131548,0.0003986226,0.0008938421,0.000401441,0.008223901,0.8729495,0.002283446,0.002609768,0.08754388],"study_design_scores_gemma":[0.001546998,0.01893813,0.005053909,0.00005498199,0.0004531422,0.001317717,0.0001347245,0.00626107,0.9553605,0.0003081045,0.01051803,0.00005270921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985987,0.006167721,0.001909586,0.0002299999,0.0002490044,0.0001917705,0.0001957506,0.0001438944,0.004925346],"genre_scores_gemma":[0.9962738,0.001427952,0.0007392966,0.0000259568,0.00003926356,0.00005233886,0.00009884941,0.00001695319,0.001325654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001842213,"threshold_uncertainty_score":0.006162763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02397662582149871,"score_gpt":0.3020503082894053,"score_spread":0.2780736824679066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}