{"id":"W2057661816","doi":"10.1371/journal.pone.0092552","title":"Defects in the C. elegans acyl-CoA Synthase, acs-3, and Nuclear Hormone Receptor, nhr-25, Cause Sensitivity to Distinct, but Overlapping Stresses","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; Terry Fox Foundation; Institut National de la Santé et de la Recherche Médicale; U.S. Public Health Service; Agence Nationale de la Recherche; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Biology; Mutant; Nuclear receptor; Innate immune system; Gene; Gene expression; Phenotype; Caenorhabditis elegans; Cell biology; Genetics; Transcription factor; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001089035,0.0008491288,0.0002317191,0.0003929735,0.000247777,0.0002997844,0.0003278439,0.0003859091,0.0009131269],"category_scores_gemma":[0.0001358608,0.0002442631,0.0005222283,0.0001247072,0.0004717548,0.0001732304,0.0004794149,0.0006708094,0.0003741106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005897614,"about_ca_system_score_gemma":0.0005683586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002777024,"about_ca_topic_score_gemma":0.005378422,"domain_scores_codex":[0.9997814,0.0000120731,0.00002590643,0.00006115825,0.00008029041,0.00003912841],"domain_scores_gemma":[0.9997403,0.00002047978,0.0001139962,0.00002332768,0.00001933783,0.00008257281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000431625,0.000007698221,0.0002593561,0.00001681222,0.000006289214,0.00006226506,0.000005464477,0.0000475299,0.9991332,0.00005051856,0.00001824011,0.0003495344],"study_design_scores_gemma":[0.00001215566,0.0000984775,0.01960455,0.00001157248,0.00003956507,0.0004361867,0.00005717978,0.001227189,0.9764289,0.00008846403,0.001977659,0.00001822918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953826,0.0005038744,0.002115858,0.00007022263,0.00003257873,0.00002041857,0.0006949946,0.0001671973,0.001012113],"genre_scores_gemma":[0.9939043,0.0003283569,0.002333608,0.0000668338,0.000004970795,0.00003440362,0.0006424659,0.00005308774,0.002631927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002777024,"threshold_uncertainty_score":0.005521774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01912302205122591,"score_gpt":0.212422109983969,"score_spread":0.1932990879327431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}