{"id":"W2057677543","doi":"10.1006/rtph.2001.1415","title":"Reply to Comment","year":2000,"lang":"en","type":"article","venue":"Regulatory Toxicology and Pharmacology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Cantox Health Sciences International","funders":"","keywords":"Endocrinology; Internal medicine; Alkaline phosphatase; Toxicity; Chemistry; Body weight; Tap water; Creatinine; Animal science; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02317088,0.001544256,0.003136781,0.002007164,0.00812235,0.01081242,0.006249732,0.1195263,0.01442424],"category_scores_gemma":[0.1308547,0.001895342,0.003229264,0.002394688,0.01173582,0.0090004,0.006684382,0.1075648,0.0127306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01049462,"about_ca_system_score_gemma":0.01117387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01315859,"about_ca_topic_score_gemma":0.01209854,"domain_scores_codex":[0.9826937,0.004145748,0.002061762,0.003375771,0.004803285,0.002919679],"domain_scores_gemma":[0.9223939,0.05231728,0.005069149,0.002629203,0.01203738,0.005553036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000389954,0.00000857534,0.0002778221,0.000057486,0.00003042676,0.0002061146,0.0003380103,0.00004292477,0.00006470553,0.002657058,0.9947386,0.001539267],"study_design_scores_gemma":[0.0001657486,0.00004462611,0.001811185,0.0006319973,0.000108069,0.0004786749,0.001724846,0.0002847252,0.000321115,0.0102697,0.9839929,0.0001664858],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0001236999,0.0004480693,0.00006717089,0.9736376,0.02510421,0.00000642692,0.00003115986,0.00001501787,0.0005666088],"genre_scores_gemma":[0.0007047142,0.0001264345,0.00004655138,0.9850588,0.01257423,0.00001721037,0.000007161865,0.00001550908,0.001449438],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1195263,"threshold_uncertainty_score":0.1225408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3338266178407151,"score_gpt":0.5470417684210886,"score_spread":0.2132151505803735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}