{"id":"W2057742112","doi":"10.1093/emboj/20.22.6434","title":"Functional involvement of G8 in the hairpin ribozyme cleavage mechanism","year":2001,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council; National Institutes of Health; Medical Research Council Canada","keywords":"Hairpin ribozyme; Protonation; Phosphodiester bond; VS ribozyme; Ribozyme; Stereochemistry; Cleavage (geology); Biology; Chemistry; Catalysis; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001350133,0.000100065,0.00009993466,0.0000353732,0.0001486765,0.00002867432,0.0003740174,0.00006038502,0.0001554011],"category_scores_gemma":[0.00004366927,0.00005513582,0.000103316,0.00008062679,0.00004419808,0.000004325179,0.00005646591,0.0001679835,0.00001266552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001114161,"about_ca_system_score_gemma":0.00004950257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001331631,"about_ca_topic_score_gemma":0.00002781839,"domain_scores_codex":[0.9989551,0.0002482224,0.000242285,0.0001120923,0.0002553066,0.0001870213],"domain_scores_gemma":[0.9995006,0.00002583316,0.0001347062,0.000262666,0.000041441,0.00003473786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001996429,0.0001126735,0.000304023,0.000005262806,0.00006065865,0.00002207521,0.0002977944,0.00008406488,0.9834751,0.005878619,0.005476808,0.004083257],"study_design_scores_gemma":[0.0009016239,0.000513499,0.00346646,0.00004163707,0.00003389806,0.0007915443,0.001419372,0.00004547861,0.9298878,0.03679658,0.02591736,0.0001847026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811563,0.0007891636,0.01312227,0.002140752,0.0003152132,0.0001848834,0.000003465782,0.000003111588,0.002284801],"genre_scores_gemma":[0.9975274,0.0004521688,0.0002370258,0.0008051519,0.000438785,0.00001301985,0.00000503746,0.00001031853,0.0005111081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05358727,"threshold_uncertainty_score":0.2248373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02364114227852234,"score_gpt":0.2383486107805496,"score_spread":0.2147074685020273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}